How do myelinating cells alter brain circuits to facilitate learning?

该项目旨在识别接受新绝缘的大脑回路，并描述这一过程的分子介体。这个项目将应用创新技术来了解神经系统如何在一生中保持适应性。这种让大脑回路在一生中保持适应性的细胞机制的新知识，可能会应用于旨在改善教育结果或抵消与年龄相关的记忆衰退的干预措施的开发。未来的潜在好处包括促进药物的开发，以避免脑部疾病导致的记忆丧失，以及改进用于计算的神经形态硬件的设计。

This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.