BCL-1: A CYCLIN/PROTO-ONCOGENE

BCL-1：细胞周期蛋白/原癌基因

• 批准号: 3071996
• 负责人: TIMOTHY C. MEEKER
• 金额: $ 6.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-30 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3071996
• 关键词: B lymphocyte; breast neoplasms; cell cycle; cell cycle proteins; chromosome translocation; gene expression; genetic mapping; genetically modified animals; human tissue; laboratory mouse; laboratory rabbit; lymphocytic leukemia; lymphoma; messenger RNA; molecular cloning; monoclonal antibody; natural gene amplification; neoplasm /cancer genetics; nucleic acid hybridization; nucleic acid probes; nucleic acid sequence; protooncogene; restriction mapping

In human leukemia and lymphoma, chromosome translocations disrupt adjacent proto-oncogenes, contributing to oncogenesis. The bcl-1 region on chromosome 11 has been defined as the location of breakpoints of the t(11;14)(q13:q32) translocation. This translocation has been associated with several types of B-cell lymphocytic lymphoma, including more than 50% of a common subtype called centrocytic (or intermediate) lymphoma. We have located the bcl-1 gene in this region of genomic DNA and determined it to be a member of the cyclin gene family. As such, it is likely to play an important role in cell-cycle progression. In this proposal we will finish our analysis of cDNA clones from this gene, determine its genomic structure and initiate studies to determine its function. While this proposal has great importance for the study of human leukemia and lymphoma, the bcl-1 gene may also have importance for a variety of solid cancers, including breast cancer. Evidence already exists that the bcl-1 locus from chromosome 11 is amplified in breast cancer, esophageal cancer, head and neck cancer, and others. We believe that the bcl-1 gene may be driving this amplification. therefore, it is our hypothesis that the bcl-1 gene is an important gene for several types of malignancy. More complete information about the bcl-1 gene will aid our understanding of how lymphomas and solid cancers arise. As bcl-1 is a member of the cyclin gene family, the close relationship that exists between the fields of cell-cycle control and cancer is dramatically emphasized. This raises the hope that new ways to manipulate the cell cycle will lead to additional advances in our ability to treat cancer.

在人类白血病和淋巴瘤中，染色体易位破坏相邻的染色体