MOLECULAR GENETICS OF HUMAN LEUKEMIA AND LYMPHOMA
人类白血病和淋巴瘤的分子遗传学
基本信息
- 批准号:3079600
- 负责人:
- 金额:$ 6.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1987
- 资助国家:美国
- 起止时间:1987-02-01 至 1992-03-31
- 项目状态:已结题
- 来源:
- 关键词:B lymphocyte acute leukemia acute lymphocytic leukemia cell differentiation chromosome disorders chromosome translocation chromosome walking chronic leukemia eosinophil genetic library genetic mapping human genetic material tag human tissue immunoglobulin genes in situ hybridization interleukin 3 lymphoma molecular cloning molecular oncology monoclonal antibody neoplasm /cancer genetics northern blottings nucleic acid sequence oncogenes point mutation southern blotting synthetic antigens transfection western blottings
项目摘要
It is clear that many B lymphocytic cancers are associated with
characteristic chromosomal abnormalities. These chromosomal aberrations
appear to result in disordered gene expression which may be fundamental to
oncogenesis. The genes that are deregulated by chromosomal abnormalities
and cause the malignant phenotype are called proto-oncogenes. This
proposal will investigate the genetic alteration resulting from the
translocation (14,18) that occurs in the majority of nodular lymphoma and
the translocation(1,19) that occurs in approximately 30% of pre-B cell
acute lymphocytic leukemia. We propose that two new oncogenes, bcl-2 and
bcl-3, are located adjacent to these points of translocation. This
proposal will focus on the cloning and characterization of these
oncogenes. This project will begin with the cloning of the breakpoints
noted above from genomic libraries and the identification of an adjacent
transcribed gene by Northern blotting. These transcribed genes will then
be cloned from cDNA libraries. The genomic and cDNA clones of these genes
(bcl-2 and bcl-3) will then be characterized by restriction mapping, S1
mapping and sequencing. In an effort to understand the range of genetic
alteration in these diseases, multiple tissue samples will be studied by
Southern blotting, Northern blotting and perhaps at the sequence level.
The cloned genes will be expressed in E. coli to isolate material to
immunize for antibody production. Similarly, the derived amino acid
sequence of the gene products will be used to make peptides to immunize
animals for antibody production for initial protein studies. This
investigation will result in an understanding of the genetic basis of human
nodular lymphoma and pre-B cell acute lymphocytic leukemia. This
investigation will lay the foundation for improved therapeutic and
preventive strategies for these diseases.
很明显,许多B淋巴细胞癌都与
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Assessing patients' experiences of cancer care across the treatment pathway: a mapping review of recent psychosocial cancer care publications.
评估患者在整个治疗路径中的癌症护理经历:对最近心理社会癌症护理出版物的绘图回顾。
- DOI:10.1007/s00520-019-04740-1
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Sanson-Fisher,Rob;Fakes,Kristy;Waller,Amy;Mackenzie,Lisa;Bryant,Jamie;Herrmann,Anne
- 通讯作者:Herrmann,Anne
The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.
急性淋巴细胞白血病病例中的 t(5;14) 染色体易位将白细胞介素 3 基因与免疫球蛋白重链基因连接起来。
- DOI:
- 发表时间:1989
- 期刊:
- 影响因子:20.3
- 作者:Grimaldi,JC;Meeker,TC
- 通讯作者:Meeker,TC
An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy.
BCL-1 基因座中的另一个断点区域与 B 淋巴细胞恶性肿瘤的 t(11;14)(q13;q32) 易位相关。
- DOI:
- 发表时间:1989
- 期刊:
- 影响因子:20.3
- 作者:Meeker,TC;Grimaldi,JC;O'Rourke,R;Louie,E;Juliusson,G;Einhorn,S
- 通讯作者:Einhorn,S
Cloning of the t(11;14)(q13;q32) translocation breakpoints from two human leukemia cell lines.
从两个人类白血病细胞系克隆 t(11;14)(q13;q32) 易位断点。
- DOI:
- 发表时间:1991
- 期刊:
- 影响因子:11.4
- 作者:Meeker,TC;Sellers,W;Harvey,R;Withers,D;Carey,K;Xiao,H;Block,AM;Dadey,B;Han,T
- 通讯作者:Han,T
Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: analysis with multiple breakpoint probes
中心细胞淋巴瘤中 11 号染色体 bcl-1 位点的重排:使用多个断点探针进行分析
- DOI:10.1182/blood.v78.2.493.493
- 发表时间:1991
- 期刊:
- 影响因子:20.3
- 作者:Michael E. Williams;T. Meeker;S. Swerdlow
- 通讯作者:S. Swerdlow
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TIMOTHY C. MEEKER其他文献
TIMOTHY C. MEEKER的其他文献
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{{ truncateString('TIMOTHY C. MEEKER', 18)}}的其他基金
MOLECULAR GENETICS OF HUMAN LEUKEMIAS AND LYMPHOMAS
人类白血病和淋巴瘤的分子遗传学
- 批准号:
3079599 - 财政年份:1987
- 资助金额:
$ 6.73万 - 项目类别:
MOLECULAR GENETICS OF HUMAN LEUKEMIAS AND LYMPHOMAS
人类白血病和淋巴瘤的分子遗传学
- 批准号:
3079598 - 财政年份:1987
- 资助金额:
$ 6.73万 - 项目类别:
MOLECULAR GENETICS OF HUMAN LEUKEMIA AND LYMPHOMA
人类白血病和淋巴瘤的分子遗传学
- 批准号:
3079597 - 财政年份:1987
- 资助金额:
$ 6.73万 - 项目类别:
MOLECULAR GENETICS OF HUMAN LEUKEMIAS AND LYMPHOMAS
人类白血病和淋巴瘤的分子遗传学
- 批准号:
3079601 - 财政年份:1987
- 资助金额:
$ 6.73万 - 项目类别:
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