DEVELOPMENT OF COMORBIDITY INDEX FOR ARTHRITIS RESEARCH

关节炎研究合并症指数的开发

• 批准号: 3068531
• 负责人: ANDREW A GUCCIONE
• 金额: $ 8.49万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-27 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3068531
• 关键词: aging; arthritis; data collection methodology /evaluation; epidemiology; functional ability; human morbidity; human old age (65+); rehabilitation; statistics /biometry; technology /technique development; training

The overall goal during the proposed five year grant period is to develop further the skills and knowledge base of an independent researcher. The research goal of this grant is to develop a comorbidity index for use in arthritis and rehabilitation research. The scope of the proposed grant includes specific elements of research, education and clinical training. Using arthritis as a model for the relationship between a disease and physical functional status, the overall research goal is to define the specific impact of arthritis on the physical function of elders accounting for the simultaneous impacts of comorbidities on function. The specific aims of the research to be undertaken during the initial phase of the grant period are to: 1) conduct a secondary data analysis of data from the Framingham Heart Study to determine the association of radiographically-defined osteoarthritis with specific medical comorbidities and 2) develop an index to account for the combined effects of other comorbidities on physical function in the elderly in arthritis-oriented functional status research. The specific aims of the educational component are to: 1) develop advanced level skill in the statistical manipulation of large data sets for epidemiological study; 2) enhance capacity in the design of clinical trials and longitudinal analyses of function and decline in the elderly; and 3) establish interdisciplinary relationships with colleagues in the Department of Geriatric Medicine and the School of Public Health at Boston University. The specific aims of the clinical training component of this grant are to: 1) obtain enhanced mastery of problems in geriatric clinical medicine and their relationship to interdisciplinary rehabilitation interventions and 2) serve as a teaching resource in physical therapy and rehabilitation to the Departments of Arthritis and Geriatrics. These aims will be accomplished through a program supervised by Boston University Arthritis Section Chief, Dr. Robert F. Meenan, MD, MPH, and conducted under the auspices of the Arthritis Section of the Boston University School of Medicine and its counterpart institution, the Boston University School of Public Health.

拟议的五年资助期内的总体目标是发展 进一步提高独立研究人员的技能和知识基础。 这 这笔赠款的研究目标是开发一个合并症指数，用于 关节炎和康复研究。 拟议拨款的范围包括具体的研究内容， 教育和临床培训。 使用关节炎作为模型 疾病与身体机能状态之间的关系，总体 研究目标是确定关节炎对身体的具体影响 老年人对合并症同时影响的作用 功能上。 期间将进行的研究的具体目标 资助期的初始阶段是： 1）进行二次数据 分析弗雷明汉心脏研究的数据以确定 放射学定义的骨关节炎与特定的相关性 医疗合并症，2) 制定一个指数来说明合并症 其他合并症对老年人身体功能的影响 以关节炎为导向的功能状态研究。 该计划的具体目标 教育内容是： 1）培养高级技能 用于流行病学研究的大数据集的统计操作； 2） 提高临床试验和纵向分析的设计能力 老年人的功能和衰退； 3）建立跨学科 与老年医学系同事的关系以及 波士顿大学公共卫生学院。 该计划的具体目标 该补助金的临床培训部分是：1）获得增强的 老年临床医学问题及其相互关系的掌握 跨学科康复干预措施，2) 作为 物理治疗和康复科的教学资源 的 关节炎和老年病学。 这些目标将通过波士顿监督的一项计划来实现 大学关节炎科主任 Robert F. Meenan 博士，医学博士、公共卫生硕士 在波士顿关节炎科的赞助下进行 大学医学院及其对应机构波士顿大学医学院 大学公共卫生学院。