DEVELOPMENT OF COMORBIDITY INDEX FOR ARTHRITIS RESEARCH

在拟议的五年赠款期间，总体目标是发展 进一步培养独立研究人员的技能和知识基础。这个 这笔赠款的研究目标是开发一种共病指数，用于 关节炎和康复研究。 拟议拨款的范围包括研究的具体内容， 教育和临床培训。使用关节炎作为动物模型 疾病与身体机能状态之间的关系，总体上 研究目标是确定关节炎对身体的具体影响 老年人在合并症同时影响中的作用 在功能上。这项研究的具体目标是 授权期的初始阶段是：1)进行二次数据 对弗雷明翰心脏研究的数据进行分析以确定 放射学定义的骨关节炎与特异性骨关节炎的相关性 医疗合并症和2)开发一个指数来解释合并的 老年人其他合并症对身体机能的影响 以关节炎为导向的功能状态研究。《公约》的具体目标 教育的组成部分是：1)发展高级技能 用于流行病学研究的大数据集的统计处理；2) 增强临床试验和纵向分析的设计能力 3)建立跨学科的研究体系 与老年医学系同事的关系和 波士顿大学公共卫生学院。《公约》的具体目标 这笔赠款的临床培训部分是：1)获得增强的 掌握老年临床医学存在的问题及其相互关系 跨学科的康复干预和2)作为 物理治疗及康复课程的教学资源 的 关节炎和老年病。 这些目标将通过波士顿监督的一个项目来实现 大学关节炎科主任，罗伯特·F·米南博士，医学博士，公共卫生硕士， 在波士顿关节炎科的赞助下进行 大学医学院及其对应的机构，波士顿 大学公共卫生学院。

The overall goal during the proposed five year grant period is to develop further the skills and knowledge base of an independent researcher. The research goal of this grant is to develop a comorbidity index for use in arthritis and rehabilitation research. The scope of the proposed grant includes specific elements of research, education and clinical training. Using arthritis as a model for the relationship between a disease and physical functional status, the overall research goal is to define the specific impact of arthritis on the physical function of elders accounting for the simultaneous impacts of comorbidities on function. The specific aims of the research to be undertaken during the initial phase of the grant period are to: 1) conduct a secondary data analysis of data from the Framingham Heart Study to determine the association of radiographically-defined osteoarthritis with specific medical comorbidities and 2) develop an index to account for the combined effects of other comorbidities on physical function in the elderly in arthritis-oriented functional status research. The specific aims of the educational component are to: 1) develop advanced level skill in the statistical manipulation of large data sets for epidemiological study; 2) enhance capacity in the design of clinical trials and longitudinal analyses of function and decline in the elderly; and 3) establish interdisciplinary relationships with colleagues in the Department of Geriatric Medicine and the School of Public Health at Boston University. The specific aims of the clinical training component of this grant are to: 1) obtain enhanced mastery of problems in geriatric clinical medicine and their relationship to interdisciplinary rehabilitation interventions and 2) serve as a teaching resource in physical therapy and rehabilitation to the Departments of Arthritis and Geriatrics. These aims will be accomplished through a program supervised by Boston University Arthritis Section Chief, Dr. Robert F. Meenan, MD, MPH, and conducted under the auspices of the Arthritis Section of the Boston University School of Medicine and its counterpart institution, the Boston University School of Public Health.