PSYCHONEUROIMMUNOLOGY AND HIV INFECTION

本提案是对ADAMHA RSDA级别的请求，重点是 加州大学洛杉矶分校的精神神经免疫学。 RSDA将由赫伯特·韦纳(Herbert Weiner)医学博士、 精神病学和约翰·L·费希，医学博士，微生物学和 免疫学和跨学科中心主任 免疫与疾病研究(CIRID)。 我在RSDA期间的目标是：1)增加对 免疫学中的方法学和概念性问题 重视与人类免疫缺陷相关的免疫病理学 病毒(艾滋病毒)，2)增加了对方法学和 生物行为科学中的概念问题，3)继续研究 论人类免疫缺陷病毒发展过程中的心理过程 感染，以及4)开始合作研究生物 心理和心理之间关系的基础路径 免疫力的影响因素和变化。 我在RSDA期间的主要研究目标是 是为了确定对暴露的特定心理反应 两种紧张的经历(患艾滋病的风险和 丧亲之痛)与免疫过程有关，预测 艾滋病的发展，以及更快的发展 参与洛杉矶多中心的HIV+RAN患者中的艾滋病 艾滋病队列研究(MACS)。此外，该项目将开始 测试两条可能连接心理过程的生物通路 HIV+男性的免疫变化：潜伏病毒的重新激活 并改变淋巴细胞对刺激的敏感性 淋巴细胞和神经肽。 我的长期目标是指导跨学科研究 心理因素、免疫过程与心理健康的关系 潜伏或慢性病毒感染的进展，特别是 感染艾滋病毒。我打算把这项研究搬到 隔离下面的生物路径的方向 心理学的特定维度之间的关系 对威胁事件和特定模式的反应 免疫反应。

This proposal is a request for an ADAMHA RSDA level focused on psychoneuroimmunology at the University of California, Los Angeles. The RSDA would be sponsored by Herbert Weiner, M.D., Professor of Psychiatry and John L. Fahey, M.D., Professor of Microbiology and Immunology and Director of the Center for Interdisciplinary Research on Immunology and Disease (CIRID). My goals for the RSDA period are: 1) increased understanding of methodological and conceptual issues in immunology, with an emphasis on immunopathology related to the Human Immunodeficiency Virus (HIV), 2) increased understanding of methodological and conceptual issues in biobehavioral sciences, 3) continued research on psychological processes as cofactors in the progression of HIV infection, and 4) to begin collaborative research on the biological pathways that underlay the relationship between psychological factors and changes in immunity. The primary objective of my research during the RSDA period will be to determine if particular psychological responses to exposure to two stressful experiences (the risk of developing AIDS and bereavement) are associated with immune processes prognostic for the development of AIDS, as well as a more rapid development of AIDS in HIV+ ran who participate in the Los Angeles Multi-Center AIDS Cohort Study (MACS). In addition, the project would begin to test two biological pathways that may link psychological processes to changes in immunity in HIV+ men: reactivation of latent viruses and altered susceptibility of lymphocytes to stimulation by lymphocytes and neuropeptides. My long-term goal is to direct interdisciplinary research on the relationships among psychological factors, immune processes and the progression of latent or chronic viral infections, particularly infection with HIV. I intend this research to move in the direction of isolating biological pathways that underlay relationships between particular dimensions of psychological response to threatening events and particular patterns of immunological response.