PSYCHONEUROIMMUNOLOGY AND HIV INFECTION

本建议书是对ADAMHA RSDA级别的要求，重点是 洛杉矶的加州大学心理神经免疫学。 RSDA将由医学博士赫伯特韦纳赞助，教授 精神病学和约翰L.费伊医学博士，微生物学教授， 免疫学和跨学科中心主任 免疫学与疾病研究（CIRID） 我在RSDA期间的目标是：1）增加对 免疫学中的方法和概念问题， 强调与人类免疫缺陷相关的免疫病理学 2）提高对方法和手段的认识， 生物行为科学中的概念问题，3）继续研究 心理过程作为艾滋病毒进展的辅助因素 感染，以及4）开始合作研究的生物 这些途径解释了心理和 免疫力的变化和变化。 我在RSDA期间研究的主要目标将是 是为了确定暴露后的特定心理反应 两种压力经历（患艾滋病的风险和 丧亲）与免疫过程有关， 艾滋病的发展，以及更迅速的发展， 参加洛杉矶多中心的艾滋病患者中的HIV+患者 艾滋病队列研究（MACS）。 此外，该项目将开始， 测试两种可能联系心理过程的生物学途径 HIV阳性男性的免疫力变化：潜伏病毒的重新激活 以及改变淋巴细胞对刺激的敏感性， 淋巴细胞和神经肽。 我的长期目标是指导跨学科研究， 心理因素、免疫过程和 潜伏或慢性病毒感染的进展，特别是 感染艾滋病毒。 我打算把这项研究 分离生物途径的方向， 心理学的特定维度之间的关系 对威胁事件的反应以及 免疫反应。

This proposal is a request for an ADAMHA RSDA level focused on psychoneuroimmunology at the University of California, Los Angeles. The RSDA would be sponsored by Herbert Weiner, M.D., Professor of Psychiatry and John L. Fahey, M.D., Professor of Microbiology and Immunology and Director of the Center for Interdisciplinary Research on Immunology and Disease (CIRID). My goals for the RSDA period are: 1) increased understanding of methodological and conceptual issues in immunology, with an emphasis on immunopathology related to the Human Immunodeficiency Virus (HIV), 2) increased understanding of methodological and conceptual issues in biobehavioral sciences, 3) continued research on psychological processes as cofactors in the progression of HIV infection, and 4) to begin collaborative research on the biological pathways that underlay the relationship between psychological factors and changes in immunity. The primary objective of my research during the RSDA period will be to determine if particular psychological responses to exposure to two stressful experiences (the risk of developing AIDS and bereavement) are associated with immune processes prognostic for the development of AIDS, as well as a more rapid development of AIDS in HIV+ ran who participate in the Los Angeles Multi-Center AIDS Cohort Study (MACS). In addition, the project would begin to test two biological pathways that may link psychological processes to changes in immunity in HIV+ men: reactivation of latent viruses and altered susceptibility of lymphocytes to stimulation by lymphocytes and neuropeptides. My long-term goal is to direct interdisciplinary research on the relationships among psychological factors, immune processes and the progression of latent or chronic viral infections, particularly infection with HIV. I intend this research to move in the direction of isolating biological pathways that underlay relationships between particular dimensions of psychological response to threatening events and particular patterns of immunological response.