CONTROL OF OVARIAN FUNCTION IN THE PRIMATE
灵长类动物卵巢功能的控制
基本信息
- 批准号:3073109
- 负责人:
- 金额:$ 5.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1984
- 资助国家:美国
- 起止时间:1984-05-01 至 1989-04-30
- 项目状态:已结题
- 来源:
- 关键词:Macaca mulatta corpus luteum estradiol experimental brain lesion follicle stimulating hormone graafian follicles hormone regulation /control mechanism hypothalamus luteinizing hormone menstrual cycle menstrual cycle disorder ovulation pituitary gonadal axis progesterone prolactin radioimmunoassay reproductive system circulation
项目摘要
The goals of research described in this application are twofold: to
elucidate the mechanisms by which a single ovulatory follicle matures each
cycle and to identify the physiological mechanisms by which the primate
corpus luteum is regulated during the rhesus monkey menstrual cycle.
Experiments presented herein will investigate whether the selected follicle
inhibits the maturation of other follicles by suppressing gonadotropin
secretion, and if the selected follicle is spared from this inhibition by
its acquisition of a rich vasculature which allows it to preferentially
receive gonadotropins. In addition, this research will define the
dependency of the primate corpus luteum on pituitary gonadotropins during
the early, mid, and late luteal phase of the menstrual cycle, identify the
nature by which the corpus luteum perceives and responds to pituitary
gonadotropins, and elucidates the site of action of estradiol in promoting
luteal regression.
In addition to providing definitive information regarding the physiological
regulation of the primate ovary in vivo, the results obtained from these
experiments may further our understanding of pathophysiological
disturbances of the human menstrual cycle such as impaired follicle growth,
the short luteal phase, and the inadequate luteal phase. Lastly, it is
becoming increasingly apparent that pulsatile GnRH treatment will be used
extensively in the treatment of certain types of amenorrhea in humans.
Studies described in this application will provide important information
regarding the maintenance of the corpus luteum in GnRH driven menstrual
cycles, and in doing so, may directly guide clinical endocrinologists in
the effective treatment of infertility.
本应用程序中描述的研究目标有两个:to
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anthony J Zeleznik其他文献
The physiology of follicle selection
- DOI:
10.1186/1477-7827-2-31 - 发表时间:
2004-06-16 - 期刊:
- 影响因子:4.700
- 作者:
Anthony J Zeleznik - 通讯作者:
Anthony J Zeleznik
Anthony J Zeleznik的其他文献
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{{ truncateString('Anthony J Zeleznik', 18)}}的其他基金
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