CONTROL OF OVARIAN FUNCTION IN THE PRIMATE

本申请中描述的研究目标有两个： 阐明单个排卵卵泡各自成熟的机制 循环和确定灵长类动物的生理机制 黄体在恒河猴的月经周期中受到调节。 这里提供的实验将调查所选的卵泡 通过抑制促性腺激素抑制其他卵泡的成熟 分泌，如果选定的卵泡不受这种抑制 它获得了丰富的血管系统，这使它能够优先 注射促性腺激素。此外，这项研究将定义 灵长类黄体对垂体促性腺激素的依赖性 月经周期的黄体早期、中期和晚期，识别 黄体感知垂体并对其作出反应的性质 促性腺激素，并阐明雌激素在促性腺激素中的作用部位 黄体退化。 除了提供有关生理学方面的明确信息 灵长类卵巢在体内的调节，由此获得的结果 实验可能会加深我们对病理生理学的理解 人类月经周期的紊乱，如卵泡生长受阻， 黄体期短，黄体期不足。最后，它是 越来越明显的是，将使用脉冲式促性腺激素释放激素治疗 广泛用于治疗人类某些类型的闭经。 本申请中描述的研究将提供重要信息 促性腺激素释放激素驱动月经时黄体的维持 周期，在这样做的过程中，可以直接指导临床内分泌学家 不孕不育的有效治疗。

The goals of research described in this application are twofold: to elucidate the mechanisms by which a single ovulatory follicle matures each cycle and to identify the physiological mechanisms by which the primate corpus luteum is regulated during the rhesus monkey menstrual cycle. Experiments presented herein will investigate whether the selected follicle inhibits the maturation of other follicles by suppressing gonadotropin secretion, and if the selected follicle is spared from this inhibition by its acquisition of a rich vasculature which allows it to preferentially receive gonadotropins. In addition, this research will define the dependency of the primate corpus luteum on pituitary gonadotropins during the early, mid, and late luteal phase of the menstrual cycle, identify the nature by which the corpus luteum perceives and responds to pituitary gonadotropins, and elucidates the site of action of estradiol in promoting luteal regression. In addition to providing definitive information regarding the physiological regulation of the primate ovary in vivo, the results obtained from these experiments may further our understanding of pathophysiological disturbances of the human menstrual cycle such as impaired follicle growth, the short luteal phase, and the inadequate luteal phase. Lastly, it is becoming increasingly apparent that pulsatile GnRH treatment will be used extensively in the treatment of certain types of amenorrhea in humans. Studies described in this application will provide important information regarding the maintenance of the corpus luteum in GnRH driven menstrual cycles, and in doing so, may directly guide clinical endocrinologists in the effective treatment of infertility.