REGIONAL VASCULAR CONTROL MECHANISMS

花生四烯酸转化为具有生物活性的级联 新陈代谢。这些衍生物包括两种环氧合酶产品，例如。 双烯类前列腺素、前列环素和血栓素；以及新的 发现了脂氧合酶的代谢物白三烯。这些脂质表现出一种 广泛的作用范围，并与各种激素系统相互作用 造成了广泛而复杂的影响。外周血管 花生四烯酸和环氧合酶代谢物的作用已被研究。 广泛地，然而，还不可能牢固地确立 这些衍生物在调节外周局部血流动力学方面具有重要作用。主修 提出的研究项目的目标是提高我们对 这些自然产生的物质在血管调节中的作用 阻力和血流的区域分布。这些研究将是 在活体动物模型中进行的天然血液条件 流。将使用非插管电磁流量探头来测量 流。将进行研究以确定花生四烯酸 在体内的肾积水模型中，新陈代谢发生改变，因为 模型可能代表了一种新的研究细胞因子功能的方法 花生四烯酸衍生物在循环控制中的作用。研究也将是 以确定脂氧合酶代谢产物是否在 这种模式，以及这些衍生品是否有能力 参与血流动力学控制机制。此外，潜在地 前列腺素对梗阻肾血流动力学的影响 将会被确定。从这些研究中获得的总体知识将 提高我们对这些强有力的内源性物质的作用的理解 对周围血管床的控制，并应提供对 高血压等疾病的治疗。

Arachidonic acid is converted to cascade of biologically active metabolities. These derivatives include both cyclooxygenase products, eg. bisenoic prostaglandins, prostacyclin and thromboxane; as well as the newly discovered lipoxygenase metabolites, leukotrienes. These lipids exhibit a wide spectrum of actions and interact with a variety of hormonal systems resulting in a wide range of complex influences. Peripheral vascular actions of arachidonate and cyclooxygenase metabolites have been studied extensively, yet it has not been possible to firmly establish a role for these derivatives in regulation of peripheral regional hemodynamics. Major goals of the propsoed research project are to improve our understanding of the role of these naturally occurring substances in regulation of vascular resistance and regional distribution of blood flow. These studies will be carried out in in vivo animal models under conditions of natural blood flow. Noncannulating electromagnetic flow probes will be used to measure flow. Studies will be carried out to determine whether arachidonic acid metabolism is altered in an in vivo model of hydroneohrosis, since such a model may represent a novel means of investigating the function of arachidonic acid derivatives in circulatory control. Studies will also be carried out to determine whether lipoxygenase metabolites are formed in this model, and whether these derivatives possess the capacity to participate in hemodynamic control mechanisms. Additionally, potentially altered hemodynamic influnces of prostaglandins in the obstructd kidney will be determined. Overall knowledge gained from these studies will improve our understanding of the role of these potent endogenous substances in control of the peripheral vascular bed, and should provide insights into treatment of diseases such as essential hypetension.