OXYGEN TRANSPORT & HEMODYNAMICS IN THE MICROVASCULATURE

我目前的研究重点是了解相关的 控制氧气的对流和扩散过程的贡献 传递，特别是如何增加血红蛋白的亲和力 氧分子对氧交换的影响。最初的一系列 这里提出的研究将使我们能够更好地描述 大微血管(小动脉和小动脉)之间的扩散相互作用 小静脉)和常氧和低氧条件下的毛细血管， 且全身性红细胞压积没有下降。接下来的两个系列 研究将使我们能够探索血红蛋白增加的影响 氧亲和力对氧传递的影响 在有和没有降低吸入氧分压水平的情况下的需氧量 和全身红细胞压积，从而测试氧气输送的极限 在这个系统中。

My current research is focused on understanding the relative contributions of convective and diffusive processes governing oxygen delivery, in particular how increasing the affinity of the hemoglobin molecule for oxygen impacts on oxygen exchange. The initial series of studies proposed here will enable us to better characterize the diffusional interactions between large microvessels (arterioles and venules) and the capillaries under normoxic and hypoxic conditions, with and without a decrease in systemic hematocrit. The next two series of studies will enable us to explore the impact of an increased hemoglobin oxygen affinity on oxygen transport in the presence of an elevated oxygen demand with and without reduced levels of inspired oxygen tension and systemic hematocrit, thereby testing the limits of oxygen delivery in this system.