课题基金 / 基金详情

HOMEOSTATIC ORIGINS OF MOTIVATION

HOMEOSTATIC ORIGINS OF MOTIVATION
动机的稳态起源
批准号:
3075693
负责人:
EDWARD M STRICKER
金额:
$5.53万
依托单位国家:
美国
项目类别:
财政年份:
1981
资助国家:
美国
项目状态:
已结题
起止时间:
1981-04-01 至 1986-03-31

项目摘要

项目成果

EDWARD M STRICKER的其他基金

相关文献

中文摘要
翻译
体液代谢的改变导致相对不足
英文摘要
Alterations in body fluid metabolism that result in relative deficiencies of water or sodium produce compensatory increases in thirst and sodium appetite, respectively. The general aim of my research is to understand the physiological bases for these drives, and their integration with complementary physiological contributions to homeostasis. In the past year I have abandoned the traditional view of thirst and sodium appetite as being stimulated by alterations in specific body fluid compartments, and now view the stimuli for these drives from the perspective of the changes they cause in the activity of neuronal systems mediating cerebral arousal. Central catecholamine-containing neurons have been demonstrated to be of critical importance to behavioral activation, and it is stimulation of these neurons during thirst that provides the present model for motivation. The specific aims of the proposed research are to evaluate this model by determining (i) the effect of thirst stimuli on activity in central catecholaminergic neurons, (ii) the importance of the pressor and dipsogenic effects of the renin-angiotensin system in rats after treatment with various hypotensive agents, (iii) the effects of hypovolemia on thirst and sodium appetite in sheep, (iv) the effects of hypovolemia on drinking behavior and on the activity of residual dopaminergic neurons in rats with dopamine-depleting brain lesions, and (v) the effects of hypovolemia on the maintenance of blood pressure and the activity of the sympathoadrenal system in rats after peripheral sympathectomy.
期刊论文(2)
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会议论文
DOI: 10.1152/ajpregu.1985.248.2.r214
发表时间: 1985
期刊: The American journal of physiology
影响因子: --
作者: [Gardiner,TW, Stricker,EM]
通讯作者: Stricker,EM
PREFRONTAL CORTICAL REGULATION OF NUCLEUS ACCUMBENS
BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA
BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA
BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA