BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA

我们为精神障碍神经科学中心(CNMD)制定的计划 以精神分裂症为重点，代表了现在的延伸 NIMH资助的神经科学和精神分裂症中心(CNS)。这个 拟建的中心继续利用众多的协作 在基础和临床的大型社区中存在的相互作用 校园里的神经学家。拟议的国家导弹防御系统的总体目标是 目的：探讨前额叶皮质在大脑中的作用。 精神分裂症的病理生理学研究 假设：精神分裂症患者的前额叶皮质功能障碍相关 导致该区域多巴胺能活动的减少，并导致 谷氨酸能投射神经元的活动。该中心将由 三个核心，一个行政(主任，E.Stricker)，一个临床 (主任，N·斯库勒)和第三次统计(主任，R.Pagano)， 和四个主要的研究项目。拟议项目5(前额 伏隔核的皮质调节；董事，E.Stricker，M. Zigmond)扩展了项目2中包含的研究 其主要关注点是谷氨酸能皮质醇的影响。 中脑边缘多巴胺神经元上的纤维。拟议项目6(突触和 他们在前额叶皮质的调制；导演，G.Barrionuevo，F. Crecl)是从CNS中的Project 1演变而来的一个新项目；其主要 重点放在前额叶结构与功能的关系上 大脑皮层神经元及单胺类神经递质的调制效应 那些神经元。拟议项目2(灵长类前额叶的组织 皮质电路；导演，D.Lewis，J.Lund，R.Moore)是一种 项目3在CNS的继续；它的主要重点是功能 猕猴前额叶皮质神经元回路的构筑 精神分裂症患者和正常人脑内同源皮质区域的研究 控制。拟议项目7(前额叶皮质在 《精神分裂症的认知功能障碍》； Cohen)是另一个新项目；其主要目标是了解 人类前额叶皮质辅助的认知功能及其 精神分裂症的损害。

Our plans for this Center for the Neuroscience of Mental disorders (CNMD) with a focus on schizophrenia, represent an extension of the present NIMH-funded Center for Neuroscience and Schizophrenia (CNS). The proposed Center continues to exploit the numerous collaborative interactions that exist within the large community of basic and clinical neuroscientists on campus. The general goals of the proposed CNMD are to investigate the involvement of prefrontal cortex in the pathophysiology of schizophrenia by testing the following main hypothesis: Prefrontal cortical dysfunction in schizophrenia is related to a reduction in dopaminergic activity in this region, and to diminished activity in glutamatergic projection neurons. The Center will consist of three cores, one Administrative (Director, E. Stricker), one Clinical (Director, N. Schooler), and the third Statistical (Director, R. Pagano), and four major research programs. Proposed Project 5 (Prefrontal Cortical Regulation of Nucleus Accumbens; Directors, E. Stricker, M. Zigmond) extends research that had been contained in Project 2 of the CNS; its main focus is on the influence of glutamatergic corticofugal fibers on mesolimbic dopamine neurons. Proposed Project 6 (Synapses and their Modulation in the Prefrontal Cortex; Directors, G. Barrionuevo, F. Crepel) is a new project that evolved from Project 1 in the CNS; its main focus is on the relation between structure and function in prefrontal cortical neurons, and the modulatory influence of monoaminergic input on those neurons. Proposed Project 2 (Organization of Primate Prefrontal Cortical Circuitry; Directors, D. Lewis, J. Lund, R. Moore) is a continuation of Project 3 in the CNS; its main focus is on the functional architecture of neuronal circuits in the prefrontal cortex of monkeys and of homologous cortical areas in brains of schizophrenics and normal human controls. Proposed Project 7 (The Role of Prefrontal Cortex in the Cognitive Dysfunctions of Schizophrenia; Directors, J. McClelland, J. Cohen) is another new project; its main goal is to understand the cognitive functions subserved by prefrontal cortex in humans, and their impairment in schizophrenia.