BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA

行为神经科学和精神分裂症

• 批准号: 2246430
• 负责人: EDWARD M STRICKER
• 金额: $ 121.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2246430
• 关键词: dopamine; frontal lobe /cortex; neurosciences; schizophrenia

Our plans for this Center for the Neuroscience of Mental disorders (CNMD) with a focus on schizophrenia, represent an extension of the present NIMH-funded Center for Neuroscience and Schizophrenia (CNS). The proposed Center continues to exploit the numerous collaborative interactions that exist within the large community of basic and clinical neuroscientists on campus. The general goals of the proposed CNMD are to investigate the involvement of prefrontal cortex in the pathophysiology of schizophrenia by testing the following main hypothesis: Prefrontal cortical dysfunction in schizophrenia is related to a reduction in dopaminergic activity in this region, and to diminished activity in glutamatergic projection neurons. The Center will consist of three cores, one Administrative (Director, E. Stricker), one Clinical (Director, N. Schooler), and the third Statistical (Director, R. Pagano), and four major research programs. Proposed Project 5 (Prefrontal Cortical Regulation of Nucleus Accumbens; Directors, E. Stricker, M. Zigmond) extends research that had been contained in Project 2 of the CNS; its main focus is on the influence of glutamatergic corticofugal fibers on mesolimbic dopamine neurons. Proposed Project 6 (Synapses and their Modulation in the Prefrontal Cortex; Directors, G. Barrionuevo, F. Crepel) is a new project that evolved from Project 1 in the CNS; its main focus is on the relation between structure and function in prefrontal cortical neurons, and the modulatory influence of monoaminergic input on those neurons. Proposed Project 2 (Organization of Primate Prefrontal Cortical Circuitry; Directors, D. Lewis, J. Lund, R. Moore) is a continuation of Project 3 in the CNS; its main focus is on the functional architecture of neuronal circuits in the prefrontal cortex of monkeys and of homologous cortical areas in brains of schizophrenics and normal human controls. Proposed Project 7 (The Role of Prefrontal Cortex in the Cognitive Dysfunctions of Schizophrenia; Directors, J. McClelland, J. Cohen) is another new project; its main goal is to understand the cognitive functions subserved by prefrontal cortex in humans, and their impairment in schizophrenia.

我们对精神障碍神经科学中心（CNMD）的计划 以精神分裂症为重点，代表了现在的延伸， NIMH资助的神经科学和精神分裂症中心（CNS）。 的 拟议的中心继续利用众多的合作 存在于基础和临床的大型社区内的相互作用 神经科学家在校园 拟议的国家导弹防御系统的总体目标是 为了研究前额叶皮层在 精神分裂症的病理生理学通过测试以下主要 假设：精神分裂症患者前额叶皮质功能障碍与 这一区域的多巴胺能活动减少， 活动的突触能投射神经元。 该中心将由 三个核心，一个行政（主任，E。Stricker），1例临床 （导演，N。Schools），and the third Statistical（Director，R.帕加诺）， 四大研究项目。 项目5（前额叶 伏隔核的皮层调节; Stricker，M. Zigmond）扩展了已包含在项目2中的研究。 中枢神经系统;其主要关注的是神经元能的离皮质激素的影响 中脑边缘多巴胺神经元上的神经纤维 建议项目6（突触及 前额叶皮层的调制; Directors，G. Barrionuevo，F. Crepel）是从CNS项目1演变而来的一个新项目;其主要 重点研究前额叶结构与功能的关系， 皮层神经元，以及单胺能输入的调节作用， 这些神经元。 拟议项目2（灵长类前额叶的组织 皮质回路;导演，D。刘易斯，J.隆德，R.摩尔）是一个 继续CNS项目3;其主要重点是功能 猴子前额叶皮层神经元回路的结构， 精神分裂症患者与正常人脑内同源皮质区的比较 对照 建议项目7（前额叶皮层在大脑中的作用） 精神分裂症的认知功能障碍;导演，J. McClelland，J. 科恩）是另一个新项目;其主要目标是了解 认知功能subserved由前额叶皮层在人类，和他们的 精神分裂症的损害。