OPIOID ANALGESICS: PHARMACOLOGICAL AND BEHAVIORAL FACTOR

这个研究科学家奖的目的是解放博士。 戴克斯特拉的大部分行政和教学工作 责任，这样她就可以把时间投入到研究中 该计划的重点是阿片类止痛药。特别强调 会被放在可能会产生有效疼痛的化合物上 松了一口气，但依赖的可能性降低了。这些措施包括 丁丙诺啡，选定的kappa激动剂和几种混合激动剂- 对抗者。止痛效果将在松鼠身上进行检验。 猴休克滴定程序和在啮齿类动物中的体温 歧视程序。作为比较，其他几种行为 将检查终端，包括计划控制、复杂的终端 条件性歧视和毒品歧视行为。在……里面 所有这些调查，重点都将放在 阿片类激动剂的行为效应与 推测为Mu和Kappa阿片受体类型的活性。按顺序 为了找出这些影响之间的关系，将进行比较 基于1)不同的行为特征和效力 不同阿片激动剂之间的关系2)阿片类激动剂的效力 阿片类拮抗剂在减弱这些激动剂的作用中的作用 它们之间发生了交叉耐受性。

The objective of this Research Scientist Award is to free Dr. Dykstra of the majority of her administrative and teaching responsibilities so that she can devote her time to a research program focused on the opioid analgesics. In particular emphasis will be placed on compounds which may provide effective pain relief, but with reduced dependence potential. These include buprenorphine, selected kappa agonists and several mixed agonist- antagonists. Analgesic effects will be examined in the squirrel monkey shock titration procedure and in rodent thermal discrimination procedure. For comparison, several other behavioral endpoints will be examined, including schedule-controlled, complex conditional discriminations and drug discrimination behavior. In all of these investigations, emphasis will be placed on the relationship between the behavioral effects of opioid agonists and presumed activity at mu and kappa opioid receptor types. In order to draw relationships between these effects, comparisons will be made on the basis of 1) differing behavioral profiles and potency relationships amongst various opioid agonists 2) the potency of opioid antagonists in attenuating effects of these agonists and 3) the occurrence of cross tolerance between them.