EPIDEMIOLOGY OF VEGETABLE DUST-INDUCED AIRWAY DISEASE

蔬菜粉尘引起的气道疾病的流行病学

• 批准号: 3081219
• 负责人: David A Schwartz
• 金额: $ 1.64万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3081219
• 关键词: agriculture worker; airborne allergen; corn; disease /disorder proneness /risk; dust; emphysema; endotoxins; farmer's lung; grain; human subject; occupational disease /disorder; pollution related respiratory disorder; questionnaires; respiratory airflow disorder; respiratory disorder epidemiology; respiratory function; respiratory toxin; soybeans; spirometry; vegetables

The overall goal of this project is to further understand the determinants and extent of respiratory disease among workers exposed to mixed grain, corn, and soybean dust. This study is designed to assess the relative contribution of specific exposures (concentration of total and respirable particulate dust, type of vegetable dust-mixed grain vs. corn vs. soybean, and level of airborne endotoxin) and their interaction with other known risk factors on the development of respiratory symptoms and airflow obstruction. This study will allow us to evaluate the safety of the threshold limit value that is currently recommended for cereal (wheat, rye, barley, and oats) grain handlers and determine whether these same threshold limit values should be recommended for noncereal grain and vegetable (corn and soybean) handlers. We will determine if respirable levels of endotoxin are more clearly related to the development of airflow obstruction than are gravimetric measures of total and respirable dust and also whether workers exposed to corn and soybean dust have a higher prevalence of chronic respiratory disorders. We will accomplish this by conducting a population-based, cross-sectional study among workers in livestock feed grain elevators, corn, mills, and soybean processing plants in Iowa. We will perform environmental measures of particulate exposures at the work site, obtain a medical and occupational history, and access spirometric function (baseline and after four hours of work). Similar measures of respiratory risks, symptoms, and function will be made on an appropriate community-based, unexposed working population. In addition to accomplishing the specific aims of this proposal, this population-based, cross-sectional study will allow us to establish a representative cohort of exposed workers for future investigations.

本项目的总体目标是进一步了解 以及工人呼吸道疾病的程度 暴露在谷物玉米和大豆的混合粉尘中 本研究旨在 评估特定接触的相对贡献（ 总粉尘和可吸入颗粒物粉尘，植物性粉尘-混合谷物 vs.玉米与大豆，以及空气中的内毒素水平）及其 与其他已知风险因素的相互作用对呼吸道疾病的发展 症状和气流阻塞。 这项研究将使我们能够评估 目前建议的阈值限值的安全性 谷物（小麦，黑麦，大麦和燕麦）谷物处理器，并确定是否 对于非谷类谷物，应推荐这些相同的阈值限值 和蔬菜（玉米和大豆）处理者。 我们将确定是否可吸入 内毒素水平与气流的发展更明显相关 比总粉尘和可吸入粉尘的重量测量更有障碍， 此外，暴露于玉米和大豆粉尘的工人是否有更高的 慢性呼吸系统疾病的患病率。 我们将通过以下方式实现这一目标： 进行了一项基于人群的横断面研究， 牲畜饲料谷物提升机、玉米、米尔斯和大豆加工厂 在爱荷华州。 我们将对颗粒暴露进行环境测量 在工作现场，获得医疗和职业史，并访问 肺功能（基线和工作4小时后）。 类似 呼吸风险、症状和功能的测量将在 适当的以社区为基础的未接触工作人群。 除了 实现这个提案的具体目标，这个以人口为基础的， 横断面研究将使我们能够建立一个代表性的队列， 暴露的工人进行未来的调查。

项目成果

The occupational history in the primary care setting.

初级保健机构的职业史。

• 发表时间: 1991
• 期刊: The American journal of medicine
• 作者: Schwartz,DA;Wakefield,DS;Fieselmann,JF;Berger-Wesley,M;Zeitler,R
• 通讯作者: Zeitler,R