CLINICAL INVESTIGATOR AWARD PROGRAM

提高血小板输注效果和效率的研究 提出了以单供体输血为主的治疗方案。 浓缩到异体免疫的病人。比较研究不同类型的 利用间接试验检测血小板抗体的方法 将采用不同的方法，并对这些方法进行评估 大批量应用的敏感性、特异性和可行性 比例。申请者还将对以下信息进行分析 2500例单一供者血小板输注前在血站 威斯康星州东南部中心，试图获得对 对供受者抗原相容的要求和其他原因 在许多患者中观察到的不同反应。在随后的研究中， 循环免疫复合体在影响机体免疫应答中的重要性 患者对单一捐献者和随机捐赠者的血小板进行调查， 以及一项前瞻性研究，以确定白细胞的减少 浓缩血小板的含量将减少或推迟同种异体免疫 实施。最后，东南部的血小板利用模式 威斯康星州将研究改善血小板输注的策略 实践将在受控的基础上进行测试。

Studies to improve the effectiveness and efficiency of platelet transfusion therapy are proposed with emphasis on transfusion of single-donor concentrates to alloimmunized patients. A comparative study of various methods for detection of platelet antibodies by indirect testing utilizing different methodologies will be undertaken, and these will be evaluated for sensitivity, specificity and feasibility of being applied on a large scale. The applicant will also undertake the analysis of information on 2,500 single-donor platelet transfusions performed previously at The Blood Center of Southeastern Wisconsin in an attempt to gain new insights into requirements for donor-recipient antigen compatibility and other causes of the variable responses observed in many patients. In subsequent studies, the importance of circulating immune complexes in affecting the response of patients to single-donor and random-donor platelets will be investigated, and a prospective study to determine whether reduction of the leukocyte content of platelet concentrates reduces or delays alloimunization will be implemented. Finally, platelet utilization patterns in southeastern Wisconsin will be studied and strategies to improve platelet transfusion practices will be tested on a controlled basis.