CLINICAL EVALUATION OF THE VESTIBULO-OCULASR REFLEX

前庭眼反射的临床评估

• 批准号: 3083572
• 负责人: Timothy C Hain
• 金额: $ 5.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3083572
• 关键词: body movement; ear disorder diagnosis; electrooculography; eye movements; head movements; human subject; labyrinth disorder; magnetic field; neurophysiology; nystagmus; stimulus /response; vertigo; vestibular apparatus; vestibuloocular reflex; vision disorders

The long term objective of our research is to better understand the mechanisms underlying both normal and abnormal vestibulo-ocular function. The aim of the present proposal is to develop new ways of testing and analyzing the vestibulo-ocular reflex (VOR). The research strategy is to make quantitative measurements of vestibulo-ocular function in humans using paradigms suggested by the results of both recent neurophysiological studies as well as mathematical analyses of VOR function. In particular, we will choose rotational vestibular and optokinetic stimuli that exceed the capabilities of or circumvent the compensatory mechanisms which normally make vestibular diagnosis so difficult. We will begin by applying the new methodology to the detection of unilateral peripheral vestibular disease (UPVD)--first in patients with complete loss, then those with partial loss--with the ultimate plan to extend our results to patients with central vestibular disorders. We plan to 1) use brief, high-velocity head-on-body movements to expose UPVD, 2) determine (with the magnetic field search coil technique) if inappropriately directed slow phase eye movements during high-velocity vertical or horizontal head rotations are a reliable index to UPVD, 3) develop a new test to measure vertical semicircular canal function by using their contribution to the horizontal (eye in head) VOR, 4) use the initial slow phase velocity profile (plateau effect), in response to a constant velocity head rotation, to detect UPVD and 5) examine the usefulness of optokinetic afternystagmus (OKAN) in assessment of UPVD. Our results will provide new information useful in the assessment of the large number of patients with nystagmus, visual blurring and oscillopsia, and vertigo and dizziness.

我们研究的长期目标是更好地理解 前庭-眼功能正常和异常的机制。 本提案的目的是开发新的测试和测试方法 分析前庭-眼反射(VOR)。研究策略是 对人类的前庭-眼功能进行定量测量 最近两项神经生理学研究的结果所暗示的范式 对VOR函数进行了研究和数学分析。特别是， 我们将选择旋转前庭和视动刺激超过 补偿机制的能力或规避补偿机制的能力 通常会使前庭诊断变得非常困难。我们将从申请开始 检测单侧外周前庭的新方法 疾病(UPVD)--首先是完全丧失的患者，然后是那些 部分损失-最终计划将我们的结果扩展到患有 中枢性前庭紊乱。我们计划1)使用简洁、高速的 头对身体的运动以暴露UPVD，2)确定(与磁性 场搜索线圈技术)如果指向不适当的慢相位眼 头部高速垂直或水平旋转期间的运动是一种 UPVD的可靠指标，3)开发了一种新的垂直测量方法 利用其对水平方向的贡献实现半规管功能 (头部眼睛)VOR，4)使用初始慢相速度剖面(平台期 效果)，以响应恒速磁头旋转来检测UPVD 和5)检查视动性后震颤(OKAN)在 UPVD的评估。我们的结果将提供新的有用的信息在 对大量眼球震颤、视力模糊患者的评估 还有震颤、眩晕和眩晕。