PHYSICIANS SCIENTIST PROGRAM AWARD

医师科学家计划奖

• 批准号: 3088059
• 负责人: SIMEON MARGOLIS
• 金额: $ 21.37万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3088059
• 关键词: medical education; postgraduate education; training

The initial objectives of our Physician Scientist Program are to provide physicians who have completed some housestaff training with a broad background in basic biomedical research as well as direct laboratory experience supervised by a basic scientist. In addition, each year two medical students will be supported to carry out a full year of basic laboratory research during a leave of abscence from the regular medical school curriculum. During Phase I of their training Physician Scientists will be enrolled in formal courses and begin laboratory work in a basic science area. All trainees will take the graduate course in Biochemistry and Molecular Biology. The selection of other course work will depend on the previous scientific background and specific research interests of each Physician Scientist. Such courses might include didactic or seminar courses taught by the faculty of the various basic science departments at the School of Medicine of subjects such as advanced chemistry, physics, or mathematics at the undergraduate campus of the University. Criteria for the choice of basic science sponsors include a stimulating laboratory environment and enthusiasm for training young scientists. An equally important criterion is that the laboratory experience will provide research training that can be applied to clinical problems in the major program areas for which the NIADDK is responsible. In Phase II of the program the Physician Scientist will work more independently, though still under the supervision of their basic science sponsor. Although many of the basic research sponsors are MD's or work on problems with immediate clinical relevance, each Physician Scientist will maintain close contact during Phase II with a secondary clinical sponsor who will help the Physician Scientist in the transition from trainee to independent investigator and in the application of basic skills to clinical research. The long-term goal of the program is to provide gifted and dedicated physicians with the opportunity to learn and utilize basic scientific tools as independent investigators working in clinical areas of interest to the NIADDK.

我们的医师科学家计划的最初目标是提供

项目成果

Energy-linked anion transport. Cloning, sequencing, and characterization of a full length cDNA encoding the rat liver mitochondrial proton/phosphate symporter.

• 发表时间: 1989-09
• 期刊: The Journal of biological chemistry
• 作者: Gloria C. Ferreira;R. Pratt;P. Pedersen

Purification and characterization of the reconstitutively active phosphate transporter from rat liver mitochondria.

大鼠肝线粒体重建活性磷酸盐转运蛋白的纯化和表征。

• 发表时间: 1986
• 期刊: The Journal of biological chemistry
• 作者: Kaplan,RS;Pratt,RD;Pedersen,PL
• 通讯作者: Pedersen,PL

Inhibition of Na+-dependent phosphate transport by group-specific covalent reagents in rat kidney brush border membrane vesicles. Evidence for the involvement of tyrosine and sulfhydryl groups on the interior of the membrane.

大鼠肾刷状缘膜囊泡中基团特异性共价试剂对 Na 依赖性磷酸盐转运的抑制。

• DOI: 10.1016/0003-9861(89)90559-6
• 发表时间: 1989
• 期刊: Archives of biochemistry and biophysics
• 影响因子: 3.9
• 作者: Pratt,RD;Pedersen,PL
• 通讯作者: Pedersen,PL

Role of complement C9 and calcium in the generation of arachidonic acid and its metabolites from rat polymorphonuclear leukocytes.

补体 C9 和钙在大鼠多形核白细胞生成花生四烯酸及其代谢物中的作用。

• DOI: 10.1016/0161-5890(87)90120-9
• 发表时间: 1987
• 期刊: Molecular immunology
• 影响因子: 3.6
• 作者: Imagawa,DK;Barbour,SE;Morgan,BP;Wright,TM;Shin,HS;Ramm,LE
• 通讯作者: Ramm,LE

Alzheimer's disease: low levels of peptide alpha-amidation activity in brain and CSF.

阿尔茨海默病：大脑和脑脊液中肽 α-酰胺化活性水平低。

• DOI: 10.1212/wnl.37.6.1057
• 发表时间: 1987
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Wand,GS;May,C;May,V;Whitehouse,PJ;Rapoport,SI;Eipper,BA
• 通讯作者: Eipper,BA