Intelligently linking nanoscience to neuroscience with glycan biology

通过聚糖生物学智能地将纳米科学与神经科学联系起来

• 批准号: DE180100206
• 负责人: Dr Lindsay Parker
• 金额: $ 29.29万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-02-12 至 2023-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100206
• 关键词: Intelligently; linking; nanoscience; neuroscience; glycan

This project aims to provide a comprehensive description of the unique cell-surface glycan expression on inflamed neurons, astrocytes, microglia and oligodendrocytes. This project will use glycan profiling data to engineer luminescent nanoparticles with superior neuroimaging qualities for cell type-specific in vivo targeting and drug delivery in the central nervous system. The project outcomes are expected to improve our fundamental understanding of neurobiological cell-surfaces.

本项目旨在提供一个全面的描述独特的细胞表面聚糖表达发炎的神经元，星形胶质细胞，小胶质细胞和少突胶质细胞。该项目将使用聚糖分析数据来设计具有上级神经成像质量的发光纳米颗粒，用于中枢神经系统中的细胞类型特异性体内靶向和药物递送。该项目的成果有望提高我们对神经生物学细胞表面的基本理解。