Connectomes arising: linking structure and function in neocortical wiring.

点击翻译按钮获取中文摘要

The cerebral cortex underpins human cognition, yet exactly how it becomes connected is unknown due to a lack of live developmental assays. We overcome this using prematurely born marsupials, which allow to study cortical development from embryo-like stages with remarkable resolution. This project will study how neural activity arises as the first connections are formed, and link functional and structural networks across development in vivo. Experimental manipulations of activity, and computational models will discover developmental rules for precise wiring of cortical connections. Benefits include new methods to study cortical development, and outlining electrical, molecular and neuroanatomical signatures of early mammalian brain formation.