REPEATED BRIEF CORONARY OCCLUSIONS: EFFECT ON FUNCTION

反复短暂的冠状动脉闭塞：对功能的影响

基本信息

批准号：
3081703
负责人：
JOHN M NICKLAS
金额：
$ 6.26万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-07-01 至 1988-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3081703
关键词：
adenosine triphosphate blood flow measurement cellular respiration collateral circulation coronary occlusion /thrombosis disease /disorder model electronic pacemaker heart circulation heart function histochemistry /cytochemistry mitochondria myocardial ischemia /hypoxia sarcoplasmic reticulum

项目摘要

Transient myocardial ischemia in man, if sufficiently brief, is generally regarded as a reversible insult from which recovery is rapid and complete. Brief coronary artery occlusion in animal models, however, has shown that regional abnormalities of myocardial contraction can be prolonged, well beyond the period of ischemia. A preliminary investigation has demonstrated that repeated brief coronary occlusions can produce progressive and significant regional ventricular dysfunction without evidence of permanent cellular injury. Since recurrent brief episodes of ischemia are known to occur in man and may be frequent and without symptoms, it is important to define the consequences of these episodes on myocardial function. This proposal will examine abnormal mechanical function in a chronic dog model following repeated brief coronary occlusions. Regional function will be measured with implanted ultrasonic time transit gauges; myocardial blood flow will be quantitated from injections of radioactively labeled microspheres; and evidence of cellular damage will be determined from histochemical stains and histology. The degree and duration of mechanical impairment will be examined as a function of the number, frequency, and duration of ischemic episodes. An attempt will be made to determine the underlying pathophysiologic mechanism by quantitative measurements of adenine neucleotides, mitochondrial respiration, and sarcoplasmic reticulum calcium uptake. Finally, therapeutic strategies to reverse or prevent the mechanical dysfunction will be examined. These studies will define the functional significance of recurrent brief episodes of ischemia and may lead to new insight into the mechanism and therapy of ischemic cardiomyopathy.

如果足够简短的话，人类的短暂性心肌缺血通常是被视为一种可逆的侮辱，恢复迅速而完整。然而，在动物模型中短暂的冠状动脉阻塞已表明心肌收缩的区域异常可以延长，很好超出缺血时期。初步调查已有证明重复的短暂冠状动力可以产生没有渐进且重要的区域心室功能障碍永久性细胞损伤的证据。由于经常出现的简短情节众所周知，缺血发生在人中，可能是频繁的，没有症状，重要的是要定义这些情节的后果心肌功能。该建议将检查异常机械重复短暂冠状动脉后，在慢性狗模型中的功能闭塞。区域功能将用植入的超声波测量时间过境仪；心肌血流将从注射放射性标记的微球；和细胞的证据损害将由组织化学染色和组织学决定。这机械障碍的程度和持续时间将作为功能检查缺血性发作的数量，频率和持续时间。尝试将通过腺嘌呤葡萄剂，线粒体的定量测量呼吸和核质网钙吸收。最后，逆转或防止机械功能障碍的治疗策略将被检查。这些研究将定义局部缺血的反复发作，并可能导致对这种新见解缺血性心肌病的机制和治疗。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Decreased coronary flow reserve after transient myocardial ischemia in dogs.

狗短暂心肌缺血后冠状动脉血流储备减少。

DOI：
10.1016/0735-1097(89)90570-6
发表时间：
1989
期刊：
Journal of the American College of Cardiology
影响因子：
24
作者：
Nicklas,JM;Gips,SJ
通讯作者：
Gips,SJ

Prospective, double-blind, placebo-controlled trial of low-dose amiodarone in patients with severe heart failure and asymptomatic frequent ventricular ectopy.

对患有严重心力衰竭和无症状频繁心室异位的患者进行低剂量胺碘酮的前瞻性、双盲、安慰剂对照试验。

DOI：
10.1016/0002-8703(91)90466-u
发表时间：
1991
期刊：
American heart journal
影响因子：
4.8
作者：
Nicklas,JM;McKenna,WJ;Stewart,RA;Mickelson,JK;Das,SK;Schork,MA;Krikler,SJ;Quain,LA;Morady,F;Pitt,B
通讯作者：
Pitt,B

Anticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation.

DOI：
10.1002/cbic.202200259
发表时间：
2022-09-16
期刊：
Chembiochem : a European journal of chemical biology
影响因子：
0
作者：
通讯作者：

Successful coronary angioplasty in two patients with cardiogenic shock using the Nimbus Hemopump support device.

使用 Nimbus 血泵支持装置成功对两名心源性休克患者进行冠状动脉成形术。

DOI：
10.1016/0002-8703(90)90217-l
发表时间：
1990
期刊：
American heart journal
影响因子：
4.8
作者：
Lincoff,AM;Popma,JJ;Bates,ER;Deeb,GM;Bolling,SF;Meagher,JS;Kelly,AM;Wampler,RK;Nicklas,JM
通讯作者：
Nicklas,JM

An algorithm for the quantification of ST-T segment variability.

ST-T 段变异性量化的算法。