IN-UTERO COCAINE EXPOSURES--NEURODEVELOPEMENT

可卡因是孕妇使用的主要非法药物， 因为对后代的风险，公众健康的关注。 在 新生儿期，这些包括低出生体重和神经行为 异常 到目前为止，还没有系统的数据， 子宫内接触可卡因的儿童的神经发育。 我们建议评估暴露于以下物质的新生儿的神经学结果： 在子宫内注射可卡因 该队列将包括约300名婴儿，约150名 可卡因暴露者和150名未暴露者，从纽约市一家医院招募 超过2年。 将通过以下方式确定妊娠期间的暴露状态： 尿液毒理学结果图表摘要，访谈自我报告， 和/或母体毛发提取物的可卡因代谢物。 我们还使用 现有的数据集，围产期艾滋病毒传播神经发育 附加研究（PI，Dr. Maria苏亚雷斯），分析宫内给药的影响 可卡因暴露对未感染儿童神经发育结果的影响 第一个目标将是确定宫内可卡因的影响 出生时暴露对结局的影响：头部大小、胎龄、宫内 生长和神经系统状况 将从人体测量数据中提取数据 测量、妊娠评估、神经系统检查和图表 抽象 第二个目标将是确定是否在子宫内 可卡因暴露与神经行为风险增加有关 孩子们的损伤一直持续到三岁。 两组婴儿（暴露和未暴露）之间的对比将 评估不利结果或减值风险是否特定于 接触可卡因的婴儿，或类似的婴儿， 种族和社会经济地位。

Cocaine is the primary illicit drug used by pregnant omen and a growing public health concern because of the risks to the offspring. In the neonatal period, these include low birth weight and neurobehavioral abnormalities. There are to date, no systematic data on the neurodevelopment of children exposed in-utero to cocaine. We propose to evaluate the neurological outcome of neonates exposed to cocaine in-utero. The cohort will comprise about 300 infants, about 150 cocaine-exposed and 150 unexposed, recruited from a single NYC hospital over 2 years. Exposure status during pregnancy will be ascertained by chart abstraction for urine toxicology results, self report by interview, and/or maternal hair extract for cocaine metabolites. In addition, we use an existing data set, the Perinatal HIV Transmission Neurodevelopment Add-On study (PI, Dr. Maria Suarez), to analyze the effects of in-utero cocaine-exposure on neurodevelopment outcome in uninfected children. A first objective will be to determine the effect of intrauterine cocaine exposure on outcomes at birth: head size, gestational age, intrauterine growth, and neurological status. Data will be drawn from anthropometric measures, gestational assessments, neurological examinations, and chart abstraction. A second objective will be to determine whether in-utero cocaine exposure is associated with an increased risk of neurobehavioral impairment in children followed until age three. Contrasts between the two groups of infants (exposed and unexposed) will assess whether the risk for adverse outcome or impairment is specific to cocaine-exposed infants, or similar to that conveyed to infants of similar racial and socioeconomical status.