课题基金 / 基金详情

NEGATIVE REGULATION OF A VITELLOGENIN PROMOTER

NEGATIVE REGULATION OF A VITELLOGENIN PROMOTER
卵黄蛋白原启动子的负调控
批准号：
3085975
负责人：
COLIN MACNEILL
金额：
$9.41万
依托单位：
RESEARCH INST OF FOX CHASE CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
项目状态：
已结题
起止时间：
1992-08-11 至 1995-07-31
来源：
https://reporter.nih.gov/project-details/3085975
关键词：
Chordata chemical binding chloramphenicol acetyltransferase complementary DNA crosslink enzyme induction /repression estrogens gel mobility shift assay gene mutation genetic promoter element genetic regulatory element genetic transcription molecular cloning nucleic acid sequence polymerase chain reaction reporter genes site directed mutagenesis training transcription factor vitellin

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中文摘要
翻译
候选人将调查雌激素依赖的假设 鸡卵黄原蛋白II基因的诱导涉及覆盖 位于启动子内的负控元件的影响。 具体目的是为了了解这一现象的分子基础。 负面对照，包括对顺式作用的准确描述 控制要素和与其绑定的因素(S)。
英文摘要
The candidate will investigate the hypothesis that estrogen-dependent induction of the chicken vitellogenin II gene involves overriding the effects of a negative control element located within the promoter. Specific aims are directed at understanding the molecular basis for this negative control, including precise descriptions of the cis-acting control element and the factor(s) that binds to it.
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