NEGATIVE REGULATION OF A VITELLOGENIN PROMOTER

卵黄蛋白原启动子的负调控

• 批准号: 2084294
• 负责人: COLIN MACNEILL
• 金额: $ 9.18万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-11 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2084294
• 关键词: Chordata; chemical binding; chloramphenicol acetyltransferase; complementary DNA; crosslink; enzyme induction /repression; estrogens; gel mobility shift assay; gene mutation; genetic promoter element; genetic regulatory element; genetic transcription; molecular cloning; nucleic acid sequence; polymerase chain reaction; reporter genes; site directed mutagenesis; training; transcription factor; vitellin

The candidate will investigate the hypothesis that estrogen-dependent induction of the chicken vitellogenin II gene involves overriding the effects of a negative control element located within the promoter. Specific aims are directed at understanding the molecular basis for this negative control, including precise descriptions of the cis-acting control element and the factor(s) that binds to it.

候选人将研究雌激素依赖性 鸡卵黄蛋白原II基因的诱导包括覆盖 位于启动子内的负控制元件的作用。 具体的目标是针对了解分子基础， 阴性对照，包括顺式作用的精确描述 控制元素和与之结合的因子。

项目成果

GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.

• 发表时间: 1994-09
• 期刊: The Journal of biological chemistry
• 作者: A. Laverriere;C. Macneill;Charles Wendell Mueller;R. Poelmann;J. Burch;T. Evans