FRACTAL AND SPATIAL DISTRIBUTION OF PULMONARY BLOOD FLOW

肺血流的分形和空间分布

• 批准号: 3083051
• 负责人: ROBB W GLENNY
• 金额: $ 7.61万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3083051
• 关键词: blood flow measurement; dogs; gravity; mathematical model; microcirculation; model design /development; pulmonary artery; pulmonary circulation; respiratory gas transport; rest; scintillation counter; vascular resistance; vasoconstriction

Fractals and fractal analysis are revolutionary mathematical concepts, touted by many as the universal geometry of nature. These new concepts are ideally suited to characterize the natural variability in physiologic form and function which have previously been described as random. They are providing new perspectives and fresh insights into pulmonary physiology. The proposed work Will use fractal analysis to further characterize the heterogeneity and spatial correlation of pulmonary blood flow distribution. Three interrelated approaches will be used. A new concept of spatial correlation, derived directly from fractal concepts, will provide a means of quantifying the degree of similarity in blood flow between spatially related regions of lung. Experiments will be performed which will quantify the relative effects of gravity, the structure of the vascular tree, and vasomotor tone on the regional heterogeneity of blood flow. The influence of these factors on the spatial correlation of blood flow will also be investigated. A three dimensional fractal model of pulmonary blood flow will be developed and will incorporate the knowledge obtained from the above studies to accurately depict the influences of the pulmonary vascular. tree and gravity on the distribution of blood. Compared to the currently accepted gravitational model, the fractal model will provide a more faithful representation of blood flow at the microcirculatory and gas exchange level.

分形和分形分析是革命性的数学 概念，被许多人吹捧为自然界的普遍几何学。 这些新 概念非常适合于描述自然变化的特征， 生理形式和功能，先前已经描述为 随机 他们提供了新的视角和新的见解， 肺生理学。 建议的工作将使用分形分析， 进一步表征肺的异质性和空间相关性， 血流分布 将采用三种相互关联的办法。 一 空间相关性的新概念，直接来自分形概念， 将提供一种量化血流相似程度的方法 在肺的空间相关区域之间。 将进行实验 这将量化重力的相对影响， 血管树和血管张力对血液区域异质性的影响 流 这些因素对血液空间相关性的影响 流量也将进行调查。 三维分形模型 肺血流将被开发，并将纳入知识 从上述研究中获得，以准确描述 肺血管 树和重力对血液分布的影响 与目前公认的引力模型相比， 将提供更真实的血流表示， 微循环和气体交换水平。