GERIATRIC DENTISTRY FOR THE ALZHEIMER'S PATIENT

1.阐明28k维生素D诱导的 钙结合蛋白(CABP)在阿尔茨海默病中的作用 疾病。死亡患者的人脑组织尸检 将对阿尔茨海默病患者进行钙分布分析 和专注力。这方面研究的目标将是 以确定CABP在本病发病机制中的作用 神经退行性疾病。这项研究将确定 神经元性钙结合蛋白的变化是否使神经元易感 间歇性的钙波动，因此容易积聚 生理上无法忍受的钙量，所有这些 可能导致细胞内钙的不受控制的升高 导致蛋白质变性和最终细胞死亡； 2.确定哪些人类染色体含有该基因。 CABP基因编码及CABP基因定位 那条染色体。 3.阐明现有临床技术的可能适用范围 以及新技术在治疗中的应用 为阿尔茨海默病患者提供高质量、低成本的牙科服务 在诊所或机构环境中对他们进行护理。一个 最新开发的可拆卸材料的光固化技术 口腔修复服务将作为此次评估的基础。

1. elucidate the relationship of the 28k Vitamin D-induced Calcium Binding Protein (CaBP) to, and its role in Alzheimer's disease. Autopsied human brain tissue from decreased patients with Alzheimer's disease will be analyzed for calcium distribution and concentration. The goal of this aspect of the research will be to ascertain the role of CaBP in the pathogenesis of this neurodengenerative disorder. The research will determine whether changes in neuronal CaBP renders neurons susceptible to intermittent calcium fluctuations and thus prone to accumulating physiologically intolerable quantities of calcium, all of which could result in an uncontrolled elevation of intracellular calcium leading to protein denaturation and eventual cell death; 2. establish which human chromosomes contains the gene coding for CaBP and to map the location of the CaBP gene on that chromosome. 3. elucidate possible adaptation of present clinical techniques and applications of new technologies in the treatment of Alzheimers' patients in order to provide quality, low-cost dental care to them in either a clinic or institutional setting. A recently-developed light-curing technique for removable prosthodontic services will serve as the basis for this evaluation.