LATENT MEMBRANE PROTEIN-1 OF EBV IN THE RECOGNITION OF INFECTED B LYMPHOCYTES

EBV 潜膜蛋白-1 在识别感染 B 淋巴细胞中的作用

• 批准号: 3839151
• 负责人: Zoya B Kurago
• 金额: --
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839151
• 关键词: B lymphocyte; Epstein Barr virus; T cell receptor; antigen presentation; clone cells; cytotoxic T lymphocyte; major histocompatibility complex; membrane proteins

Epstein-Barr virus (EBV), a member of the herpes virus family, infects most humans and may remain in the body indefinitely, generally in the form of a latent infection. EBV can transform B- lymphocytes and cause their immortalization. EBV is said to be the cause of a number of diseases including malignancies in the immunocompromised patients. T-lymphocytes are of primary importance in controlling the transformed B-cell population. Some of the latent viral proteins are known to be important in the recognition of infected B- lymphocytes by killer T-lymphocytes. This project is designed to study T-cell cytolytic clones, that recognize portions of the Latent Membrane Protein-1 (LMP-1), which are presented to the T-cell receptor by Class I major histocompatibility complex molecules (MHC). Approximately 100 cytolytic T-cell clones have already been generated against EBV- infected B-cells and partially characterized.

EB 病毒 (EBV) 是疱疹病毒家族的成员， 感染大多数人并可能无限期地留在体内， 一般以潜伏感染的形式出现。 EBV可以转化B- 淋巴细胞并使其永生化。据说EBV是 导致多种疾病，包括恶性肿瘤 免疫功能低下的患者。 T 淋巴细胞在控制 转化的 B 细胞群。一些潜伏的病毒蛋白 已知对于识别受感染的 B-很重要 淋巴细胞由杀伤性T淋巴细胞组成。 该项目旨在研究 T 细胞溶细胞克隆， 识别潜膜蛋白 1 (LMP-1) 的部分， 由 I 类主要呈递给 T 细胞受体 组织相容性复合体分子 (MHC)。约100 针对 EBV 的溶细胞 T 细胞克隆已经产生 感染的 B 细胞并部分表征。