LATENT MEMBRANE PROTEIN-1 OF EBV IN THE RECOGNITION OF INFECTED B LYMPHOCYTES

EB病毒（EBV），疱疹病毒家族的一员， 感染了大多数人，并可能无限期地留在体内， 一般是以潜伏感染的形式EB病毒可以转化B- 淋巴细胞并使其永生化。EB病毒被认为是 许多疾病的原因，包括恶性肿瘤， 免疫功能低下的患者。 T淋巴细胞在控制免疫系统中起着至关重要的作用。 转化的B细胞群。一些潜伏的病毒蛋白 在识别感染的B- 杀伤性T淋巴细胞。 该项目旨在研究T细胞溶细胞克隆， 识别潜伏膜蛋白-1（LMP-1）的部分， 由I类主要抗原呈递给T细胞受体 组织相容性复合物分子（MHC）。大约100 已经产生了针对EBV的溶细胞T细胞克隆， 感染的B细胞和部分特征。

Epstein-Barr virus (EBV), a member of the herpes virus family, infects most humans and may remain in the body indefinitely, generally in the form of a latent infection. EBV can transform B- lymphocytes and cause their immortalization. EBV is said to be the cause of a number of diseases including malignancies in the immunocompromised patients. T-lymphocytes are of primary importance in controlling the transformed B-cell population. Some of the latent viral proteins are known to be important in the recognition of infected B- lymphocytes by killer T-lymphocytes. This project is designed to study T-cell cytolytic clones, that recognize portions of the Latent Membrane Protein-1 (LMP-1), which are presented to the T-cell receptor by Class I major histocompatibility complex molecules (MHC). Approximately 100 cytolytic T-cell clones have already been generated against EBV- infected B-cells and partially characterized.