Uncovering vertebrate lifespan biodiversity with whole genome sequencing

通过全基因组测序揭示脊椎动物寿命多样性

• 批准号: DP180104195
• 负责人: Dr Matthew McGee
• 金额: $ 27.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180104195
• 关键词: Uncovering; vertebrate; lifespan; biodiversity; whole

This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. This will provide significant benefits, such as long-term implications for aging research, with possible business applications. It will also increase Australia’s visibility and competitiveness in the developing field of bioinformatics.

本项目旨在利用全基因组测序和比较系统基因组学相结合的新方法，整合模型系统中寿命进化遗传机制的现有数据，揭示脊椎动物寿命进化的共同基因组特征。预期的结果包括对寿命演变的看法，这是澳大利亚和其他发达国家对主要健康问题感兴趣的主题。这将带来巨大的好处，比如对老龄化研究的长期影响，以及可能的商业应用。它还将提高澳大利亚在发展中的生物信息学领域的知名度和竞争力。