INFECTIOUS DISEASES AND MICROBIOLOGY

传染病和微生物学

• 批准号: 3805853
• 负责人: E DONNALL THOMAS
• 金额: --
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3805853
• 关键词: Betaherpesvirinae; Candida albicans; Pneumocystis pneumonia; aminoglycoside antibiotics; amphotericin B; antifungal agents; aspergillosis; bacterial pneumonia; biomedical facility; blood chemistry; bone marrow transplantation; candidiasis; cephalosporins; combination chemotherapy; dogs; gentamicins; histocompatibility typing; homologous transplantation; human subject; microorganism classification; microorganism disease chemotherapy; secondary infection; serotyping; trimethoprim; vancomycin; viral pneumonia

Infectious complications have a major impact on the outcome of marrow transplantation. The identification, prophylaxis and treatment of infection provide data which are used by all the research projects supported by this grant. These data are collected in a database organized and administered by personnel supported in this subproject. The intensive infection control support provided for both the marrow transplant recipients and the research projects of this grant creates a valuable opportunity for studies of infection prophylaxis and treatment. We propose studies which will explore effective means of preventing infection in both laminar air flow and conventional hospital rooms. We will study the practicality of selective bacterial decontamination and its effectiveness as an alternative to total decontamination in reducing infection acquisition and the incidence of GVHD. We will also explore new methods of total decontamination to improve the effectiveness of this procedure. Finally, we propose studies of infection control during the prolonged period of immunoincompetence after engraftment.

感染性并发症对治疗结果有重大影响。 骨髓移植 识别、预防和 感染治疗提供的数据， 这些研究项目得到了资助。 这些数据 收集在由人员组织和管理的数据库中 在这个子项目中得到支持。 为两个地区提供的强化感染控制支持 骨髓移植受者和研究项目， 格兰特为感染研究创造了宝贵的机会 预防和治疗。 我们提出的研究将探讨 有效的预防感染的方法， 和传统的医院病房 我们将研究 选择性细菌去污及其作为 减少感染的全面去污替代方案 获得和GVHD的发生率。 我们还将探索新的 全面去污的方法，以提高效率， 这个程序。 最后，我们建议研究感染控制 在免疫功能不全的长期期间， 移植