AUTOLOGOUS MARROW TRANSPLANTATION

实验室和临床研究计划旨在 了解自体骨髓移植的过程 (AMI)，并改进其结果。实验室项目 将致力于更好地理解 为了设计改善骨髓的方法而进行造血术 急性心肌梗死后的功能。其他实验室项目将针对 用裂解法去除骨髓中的恶性细胞群 单抗和补体或通过积极选择 造血祖细胞。体外检测方法 净化后残留的恶性细胞也将被评估。 临床研究将涉及急性淋巴母细胞白血病患者 白血病、急性非淋巴细胞性白血病、恶性淋巴瘤和 多发性骨髓瘤，将针对定义的作用 AMT在治疗这些疾病中的作用以及探索途径 为了使用新的准备方案来改善目前的结果，更好的 体外净化和移植后生物反应调节剂。 核心方案，对开展拟议研究至关重要 项目，包括生物统计和信息服务， 病理学、门诊护理和长期随访，以及 行政部门。

A program of laboratory and clinical research directed at understanding the process of autologous marrow transplantation (AMI) and improving its results is proposed. Laboratory projects will be directed toward better understanding of the mechanisms of hematopoiesis in order to design methods of improving marrow function after AMI. Other laboratory projects will be directed at removing populations of malignant cells from marrow by lysis with monoclonal antibodies and complement or by positively selecting for hematopoietic progenitor cells. In vitro methods of detecting residual malignant cells after purging will also be evaluated. Clinical research will involve patients with acute lymphoblastic leukemia, acute nonlymphoblastic leukemia, malignant lymphoma, and multiple myeloma and will be directed towards defining the role of AMT in the treatment of these diseases as well as exploring ways to improve current results using new preparative regimens, better in vitro purging, and post-transplant biologic response modifiers. Core programs, essential in carrying out the proposed research projects, include Biostatistics and Information Services, Pathology, Outpatient Care and Long-term Follow-up, and Administration.