RELATIONSHIP OF CERVICAL INTRAEPITHELIAL NEOPLASIA III AND HPV

宫颈上皮内瘤变Ⅲ型与HPV的关系

• 批准号: 3816990
• 负责人: JOSEPH CHU
• 金额: --
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3816990
• 关键词: Betaherpesvirinae; Chlamydia trachomatis; antiviral antibody; biopsy; cancer risk; case history; cervical /vaginal smear; cervix neoplasms; epithelium; female; female antifertility drug; folate; genetic manipulation; herpes simplex virus 2; histopathology; human papillomavirus; human subject; in situ hybridization; interview; molecular oncology; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplasm /cancer invasiveness; nutrition related neoplasm /cancer; nutrition related tag; retinoids; serology /serodiagnosis; sex behavior; sexually transmitted diseases; tobacco abuse; viral carcinogenesis; young adult human (21-34)

The purposes of this study will be 1) to determine the HPV types associated with pre-cancerous cervical lesions, cervical intraepithelial neoplasia III (CIN III), also called carcinoma-in- situ; 2) to determine the presence and possible involvement of other infectious agents, such as HSV-II, CMV, and chlamydia; and 3) to ascertain the effect of other exposures, such as smoking, contraceptive method (oral contraceptives), and nutrition. This population-based case-control study will identify women 45 years old or less in Group Health Cooperative of King County, one of the largest HMOs in the United States, with newly diagnosed CIN III from October, 1986 through March, 1991. We plan to identify the cases through the Pathology Department of Group Health and the Cancer Surveillance System, a population-based cancer registry. We estimate we will be able to interview approximately 350 cases of carcinoma-in-situ (CIN III). The control group will consist of approximately 350 women of the same ages and county of residence who are identified through the enrollment files of Group Health. All previous cytologic specimens of cases and controls will be collected and evaluated for the presence of HPV by means of in-situ hybridization and cytologic features. The histologic specimens of all cases will also be tested for specific HPV types, HSV-II, and CMV. Data from an in-person interview and blood will also be collected.

这项研究的目的将是1)确定HPV的类型 与癌前病变相关，宫颈 上皮内瘤变III(CIN III)，又称癌-in-in- 现场；2)确定存在和可能参与的 其他感染性病原体，如单纯疱疹病毒2型、巨细胞病毒和衣原体；以及 3)确定其他暴露的影响，如吸烟； 避孕方法(口服避孕药)和营养。这 以人口为基础的病例对照研究将确定45岁的女性 年事已高或以下的金县团体卫生合作社，其中之一 美国最大的医疗保健组织，新诊断为CIN 三、1986年10月至1991年3月。我们计划找出 通过团体卫生病理科的病例 以及癌症监测系统，一种以人群为基础的癌症 注册表。我们估计我们将能够采访 约350例原位癌(CIN III)。这个 控制组将由大约350名妇女组成 相同的年龄和居住的县，通过 团体健康的招生档案。所有以前的细胞学 将收集病例和对照的样本并进行评估 用原位杂交的方法检测HPV的存在 细胞学特征。所有病例的组织标本都将 也要对特定的HPV类型、HSV-II和CMV进行检测。数据 通过面对面的采访，还将采集血液。