CHEMOPREVENTION (OR PREVENTION) OF CERVICAL CANCER WITH FOLIC ACID

这是一项继续研究的建议， 在第一CPRU计划项目赠款资助。 的 叶酸化学预防宫颈癌研究（CCCFAS） 目前正处于第二年的病人积累。 目的 这项双盲随机对照试验的目的是 口服叶酸治疗在预防 宫颈癌高危患者（这些妇女 活检证实轻度或中度发育不良或巨噬细胞 Escherichia）。 主要研究终点是发育不良的消退 这是通过子宫颈抹片检查和阴道镜检查确定的。 由于两个多月的延误， 开始患者累积的年数，由于无法 NCI及其承包商提供叶酸和安慰剂 以及漫长的FDA审批程序。

This is a proposal for the continuation of a study originally funded in the first CPRU Program Project Grant. The Chemoprevention of Cervical Cancer with Folic Acid Study (CCCFAS) is presently in its second year of patient accrual. The purpose of this double-blind randomized-controlled trial is to determine the effectiveness of oral folic acid therapy in preventing the development of cervical cancer in high-risk patients (those women with biopsy-proven mild or moderate dysplasia or koliocytotic atypia). The major study endpoint is the regression of dysplasia which is ascertained by PAP smear and colposcopy. A continuation was made necessary because of a delay of over two years in beginning patient accrual, due to the inability of the NCI and its contractor to provide the folic acid and placebo tablets and the lengthy FDA approval process.