THERMAL DOSIMETRY IN CANCER THERMOTHERAPY

癌症治疗中的热剂量测定

• 批准号: 3816520
• 负责人: H FREDERICK BOWMAN
• 金额: --
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3816520
• 关键词: anesthesia; clinical biomedical equipment; heat stimulus; laboratory mouse; laboratory rat; neoplasm /cancer thermotherapy; nonhuman therapy evaluation; oxygen tension; perfusion; radiation dosage; thermometry

The purpose of this project is to provide the means and methodology by which some of the major determinants of the effectiveness of various cancer therapies (hyperthermia, radiation and chemo) may be isolated and identified. Factors at the local tissue level which are recognized as central to the tumoricidal action of these therapies, either alone or in combination, include: temperature, perfusion, oxygen tension, tissue thermal conductivity and diffusivity, and specific absorption rate. These quantities will be measured using both the enhanced thermal diffusion probe (ETDP) and the multisensor Profilometer instrumentation systems. The first objective of this project is to integrate the ETDP and Profilometer systems into the scanned, intensity modulated, focused ultrasound (SIMFU) hyperthermia delivery system to provide 1) improved thermal dosimetric capabilities for pre- therapy predictive and post-therapy reconstructive thermal modeling, and 2) the necessary density of measurement information from a limited number of invasive proves to allow realistic spatio-temporal monitoring and control of treatment temperature uniformity. The second objective is to examine the temporal and spatial dependence of perfusion and oxygen tension in normal and tumor tissue, under normo- and hyperthermia, and under the influence of other stimuli such as anesthesia. In one series of experiments, uniform temperature elevations in relatively large tissue volumes will be generated by the SIMFU system and controlled by means of multiple tissue temperature measurements with the Profilometer. Power requirements and tissue temperature variations will be monitored and related to bulk and local perfusion variations. This approach combines both the generation of tissue hyperthermia and measurement of of its effects into a unified experimental procedure. In related, concurrent experiments, the ETDP and Profilometer will be used to simultaneously measure tissue perfusion, oxygen tension, and other properties during various clinical interventions. This project makes possible local, multiple measurements of these crucial tissue properties, providing the means to examine their interrelationships and the thermal dosimetry essential for the improvement of the clinical hyperthermia systems in this PPG.

该项目的目的是提供手段和 一些主要决定因素的方法， 各种癌症治疗（热疗、放射治疗）的有效性 和化疗）可以被分离和鉴定。 当地因素 组织水平，被认为是杀肿瘤的中心 这些疗法的作用（单独或组合）包括： 温度、灌注、氧张力、组织热 电导率和扩散率以及比吸收率。 这些 数量将使用增强的热测量， 扩散探针（ETDP）和多传感器轮廓仪 仪表系统。 该项目的第一个目标是整合ETDP和 轮廓仪系统的扫描，强度调制， 聚焦超声（SIMFU）热疗输送系统， 提供1）改进的预热剂量测定能力 治疗预测和治疗后重建热 建模，以及2）必要的测量密度 来自有限数量的侵入性证据的信息 治疗的真实时空监测和控制 温度均匀性 第二个目标是审查时间和空间 正常人和肿瘤的灌注和氧分压依赖性 组织，在常温和高温下，以及在 其他刺激，如麻醉。 在一系列实验中， 在相对较大的组织体积中均匀升温 将由SIMFU系统产生，并通过 多个组织温度测量， 轮廓仪。 功率要求和组织温度 将对变化进行监测，并将其与批量和本地 灌注变化。 这种方法结合了生成 组织热疗及其效果的测量 统一的实验程序。 相关的，并发的 实验中，ETDP和轮廓仪将用于 同时测量组织灌注、氧分压， 在各种临床干预期间的其他属性。 该项目使得对这些区域进行局部、多重测量成为可能。 关键的组织特性，提供检查其 的相互关系和热剂量测定的必要性， 改进PPG中的临床热疗系统。