CORE--BEHAVIORAL SCIENCE

行为科学核心有两个组成部分：共享资源，或 服务和行为科学研究。第一个集中资源 为支持已制定的干预措施：(1)通过以下方式化学预防皮肤癌 类维A酸；(2)光化性角化病I期和II期试验；(2)β-胡萝卜素 临床药理研究；(3)β-胡萝卜素和维生素E临床研究 药理学研究；以及(4)口腔白斑的II期试验 行为组件。共享资源部分的目标是：(1) 加强上述所有试验的依从性/遵从性；(2)行为 为适用的发展研究提供科学支持；和(3)咨询 与其他核心和项目合作。研究部分的假设是： (1)根据癌症患者的健康行为制定依从性增强策略 预防模型预测癌症的短期和长期依从性 预防和控制试验样本；(2)健康行为特征不同 对于好的、边缘的和差的粘附者；(3)粘附性的增强 战略与良好的坚守有关。相关描述性 H3的设计是一项针对穷人的前瞻性病例对照研究 以及边缘编译器和匹配的良好编译器控制，在 N&gt；-100。病例对照研究样本估计数为84 研究边缘/差劲的合规者的水平。DFMO/Retin-A试验(n=120) 受试者为40-80岁的男性。第二期口腔白斑的受试者 (n=143)受试者也是大约40-80岁的男性和女性。其他 试验的受试者不到100人。对H1的分析包括OLS和LOGIT， H2和H3的图形分析，以及H3的条件日志。学习 结果包括对依从性因素的描述和解释 失败，考验着通用性和个别性的有效性 合规干预。

The Behavioral Sciences Core has two components: shared resource, or service, and behavioral science research. The first centralizes resources to support developed interventions: (1) Chemoprevention of Skin Cancer by Retinoids; (2) Actinic Keratosis Phase I and II trials; (2) Beta-carotene clinical pharmacology study; (3) Beta-carotene and Vitamin E clinical pharmacology study; and (4) Phase II oral leukoplakia trials with behavioral components. The aims of the shared resource component are: (1) adherence/compliance enhancement for all trials named above; (2) Behavioral science support for applicable developmental studies; and (3) Consultation with other Cores and projects. Hypotheses for the research component are: (1) the adherence enhancement strategy per the Health Behavior in Cancer Prevention Model predicts short and long term adherence in cancer prevention and control trial samples; (2) Health Behavior Profiles differ for good, marginal and poor adherers; (3) The adherence enhancement strategy is associated with good adherence. The correlational descriptive design for H3 is a prospective case control study of a subsample of poor and marginal compliers with matched good complier controls in trials with n>-100. The case control study sample estimate is 84 based on current study levels of marginal/poor compliers. DFMO/Retin-A (n=120) trial subjects are 40-80 year old men. Subjects in the Phase II oral leukoplakia (n=143) trial are also approximately 40-80 years old men and women. Other trials have less than 100 subjects. Analyses for H1 include OLS and LOGIT, graphic analysis for H2 and H3, and conditional LOGIT for H3. Study outcomes include description and explanation of factors in adherence failure, and a test of the effectiveness of the general and individualized compliance interventions.