CORE--BEHAVIORAL SCIENCE

核心——行为科学

• 批准号: 3812250
• 负责人: JAN ATWOOD
• 金额: --
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3812250
• 关键词: behavior modification; behavioral medicine; biomedical facility; cancer prevention; clinical trials; human subject; neoplasm /cancer nutrition therapy; retinoids; therapy compliance

The Behavioral Sciences Core has two components: shared resource, or service, and behavioral science research. The first centralizes resources to support developed interventions: (1) Chemoprevention of Skin Cancer by Retinoids; (2) Actinic Keratosis Phase I and II trials; (2) Beta-carotene clinical pharmacology study; (3) Beta-carotene and Vitamin E clinical pharmacology study; and (4) Phase II oral leukoplakia trials with behavioral components. The aims of the shared resource component are: (1) adherence/compliance enhancement for all trials named above; (2) Behavioral science support for applicable developmental studies; and (3) Consultation with other Cores and projects. Hypotheses for the research component are: (1) the adherence enhancement strategy per the Health Behavior in Cancer Prevention Model predicts short and long term adherence in cancer prevention and control trial samples; (2) Health Behavior Profiles differ for good, marginal and poor adherers; (3) The adherence enhancement strategy is associated with good adherence. The correlational descriptive design for H3 is a prospective case control study of a subsample of poor and marginal compliers with matched good complier controls in trials with n>-100. The case control study sample estimate is 84 based on current study levels of marginal/poor compliers. DFMO/Retin-A (n=120) trial subjects are 40-80 year old men. Subjects in the Phase II oral leukoplakia (n=143) trial are also approximately 40-80 years old men and women. Other trials have less than 100 subjects. Analyses for H1 include OLS and LOGIT, graphic analysis for H2 and H3, and conditional LOGIT for H3. Study outcomes include description and explanation of factors in adherence failure, and a test of the effectiveness of the general and individualized compliance interventions.

行为科学核心有两个组成部分：共享资源，或 服务和行为科学研究。 第一种是集中资源 支持已制定的干预措施：（1）皮肤癌的化学预防， 类维生素A;（2）光化性角化病I期和II期试验;（2）β-胡萝卜素 临床药理学研究;（3）β-胡萝卜素和维生素E临床 药理学研究;和（4）II期口腔白斑试验， 行为成分 共享资源部分的目标是：（1） 上述所有试验的依从性/依从性增强;（2）行为 为适用的发展研究提供科学支援;及（3）谘询 与其他核心和项目。 研究部分的假设是： (1)根据癌症健康行为的依从性增强策略 预防模型预测癌症的短期和长期依从性 预防和控制试验样本;（2）健康行为概况不同 对于良好、边缘和差的粘附者;（3）粘附增强 策略与良好的遵守有关。 相关描述 H3设计是一项前瞻性病例对照研究， 以及在试验中具有匹配的良好编译器控制的边缘编译器， n>-100。 根据目前的情况，病例对照研究样本估计值为84 研究边缘/差的遵守者的水平。 DFMO/Retin-A（n=120）试验 受试者是40-80岁的男性。 II期口腔白斑受试者 （n=143）试验对象也是大约40-80岁的男性和女性。 其他 试验对象少于100人。 H1的分析包括OLS和LOGIT， H2和H3的图形分析，H3的条件LOGIT。 研究 结果包括对依从性因素的描述和解释 失败，和测试的有效性，一般和个性化的 合规干预。