INTRACOCHLEAR ELECTRICAL FIELD ANALYSIS

这个项目的目的是描述电场模式 由不同的耳蜗内电极阵列在耳蜗内产生 配置。猫和人类耳蜗的现场模型将是 使用有限元技术进行构造和评估。这些型号 将以渐进的方式构建，首先从 对精细解剖结构[例如血液]的影响的研究 骨穿血管、各向异性神经束、骨穿孔区 螺旋板]在简单自组织中的势场和电流通量 模特们。一旦所需的适当水平的解剖细节 准确的视野模型已经建立，然后组织切片 猫和人类的耳蜗将被数字化，以包括适当的 结构。对当前和潜在领域的详细分析将在 为临床应用和实验电极进行的，以及 模型的预测将通过电场测量得到验证 在猫的耳蜗里。此外，新的电极配置解决了 人类耳蜗骨的解剖学细节及变量问题 神经存活将在模型研究中进行评估。

The purpose of this project is to describe the electrical field patterns generated within the cochlea by various intracochlear electrode array configurations. Field models of the cat and human cochleae will be constructed and evaluated using finite-element techniques. These models will be constructed in a progressive manner beginning first with investigations of the effects of fine anatomical structures [e.g. blood vessel through bone, anisotropic nerve bundle, perforated zone of the bony spiral lamina] on potential fields and current fluxes in simple ad hoc models. Once the appropriate level of anatomical detail required for accurate field models has been established, then histological sections of cat and human cochleae will be digitized to include the appropriate structures. Detailed analyses of current and potential fields will be conducted for clinically-applied and experimental electrodes, and the models' predictions will be validated by measurements of electrical fields in the cat cochlea. In addition, new electrode configurations that address the anatomical details of the human cochlea and the problem of variable neural survival will be evaluated in model studies.