INTRACOCHLEAR ELECTRICAL FIELD ANALYSIS

这个项目的目的是描述电场模式 由各种耳蜗内电极阵列在耳蜗内产生 配置. 猫和人类耳蜗的场模型将被 使用有限元技术构建和评估。 这些模型 将以渐进的方式建造，首先是 精细解剖结构影响的研究[如血液 穿骨血管，各向异性神经束，骨穿孔带 螺旋层]对简单自组织中位场和电流通量影响 模型 一旦解剖细节的适当水平， 建立了准确的场模型，然后组织切片， 猫和人类耳蜗将被数字化， 结构. 详细分析当前和潜在的领域将 进行临床应用和实验电极， 模型的预测将通过测量电场来验证 在猫的耳蜗里 此外，新的电极配置， 人类耳蜗的解剖细节和变量的问题 将在模型研究中评价神经存活。

The purpose of this project is to describe the electrical field patterns generated within the cochlea by various intracochlear electrode array configurations. Field models of the cat and human cochleae will be constructed and evaluated using finite-element techniques. These models will be constructed in a progressive manner beginning first with investigations of the effects of fine anatomical structures [e.g. blood vessel through bone, anisotropic nerve bundle, perforated zone of the bony spiral lamina] on potential fields and current fluxes in simple ad hoc models. Once the appropriate level of anatomical detail required for accurate field models has been established, then histological sections of cat and human cochleae will be digitized to include the appropriate structures. Detailed analyses of current and potential fields will be conducted for clinically-applied and experimental electrodes, and the models' predictions will be validated by measurements of electrical fields in the cat cochlea. In addition, new electrode configurations that address the anatomical details of the human cochlea and the problem of variable neural survival will be evaluated in model studies.