CENTRAL MECHANISMS--CELLULAR GENERATORS OF EVOKED RESPONSES

脑干听觉诱发电位（BAEP）是一种对短暂的 声刺激，并反映在听觉神经细胞的活动 和脑干 因为它可以从头部表面测量， BAEP提供了对较低听觉系统功能的非侵入性监测。 尽管BAEP在临床上是常规使用的，但通过BAEP的细胞机制， 它是如何产生的还不清楚。 我们的目标是发展一个 在细胞水平上的猫BAEP的生成模型。 为了实现这一目标，我们建议通过以下方式对势场的产生进行建模： 单独的放电单元。 我们将制定一个细胞模型来描述 跨膜电流是如何由放电的神经元产生的， 头部模型来描述由那些 水流 模型将为cat实现;单元模型将为 针对各种听觉脑干神经元实施。 的可选值 将在实现中使用细胞和头部模型参数，并且 将进行实验以确定剩余的参数值。 已知电流源产生的电势分布 将测量麻醉猫的头部;头部模型参数值 将进行调整，以便从头部模型计算的电位符合 测量. 听觉个体放电产生的电位 脑干神经元将使用尖峰触发的方法测量 平均;细胞模型参数值将被调整， 使用细胞和头部模型计算的电位与测量的电位相匹配。 一个 BAEP的总体理论将使临床和研究应用 在一个比目前明显的更健全的基础上， 新的实际用途。

The brainstem auditory evoked potential (BAEP) is a response to a transient acoustic stimulus, and reflects the activity of cells in the auditory nerve and brainstem. Because it can be measured from the surface of the head, the BAEP provides a noninvasive monitor of lower auditory system function. Although the BAEP is routinely used clinically, the cellular mechanisms by which it is generated are not yet understood. Our goal is to develop a model for the generation of the cat BAEP based at the cellular level. Toward that goal, we propose to model the production of potential fields by individual discharging cells. We will formulate a cell model to describe how transmembrane currents are generated by a discharging neuron, and a head model to describe the potential distribution produced by those currents. The models will be implemented for cat; the cell model will be implemented for various auditory brain-stem neurons. Available values for cell and head-model parameters will be used in the implementations, and experiments will be performed to determine the remaining parameter values. Potential distributions produced by known current sources placed in the heads of anesthetized cats will be measured; head-model parameter values will be adjusted so that potentials calculated from the head model fit the measurements. Potentials produced by individual discharging auditory brainstem neurons will be measured using the method of spike-triggered averaging; cell-model parameter values will be adjusted so that potentials calculated using the cell and head models match measured potentials. An overall theory for the BAEP will place clinical and research applications on a far sounder basis than is obvious at present and will suggest hosts of new practical uses.