BLACK RACE, BODY COMPOSITION, AND OSTEOPOROSIS

黑人种族、身体成分和骨质疏松症

• 批准号: 3840250
• 负责人: JOHN F ALOIA
• 金额: --
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3840250
• 关键词: African American; activation analysis; aging; body composition; body water; bone density; calcification; calcium; carbon; densitometry; fat body; female; human middle age (35-64); human old age (65+); human subject; isotope dilution method; longitudinal human study; nitrogen; osteoporosis; physiologic bone resorption; potassium; racial /ethnic difference; young adult human (21-34)

The long-term objective of this study is to develop strategies for the prevention of osteoporosis in black women. Most studies have excluded racial minorities to limit extraneous variation. However, the number of black women over 65 years of age is increasing rapidly. An increase in longevity of 5-6 years is expected to cause a doubling of incidence rates. A comprehensive model for involutional loss of body cell mass and bone mass developed for white women, and strategies for prevention of osteoporosis, must be developed for bone loss in minority women. Body cell mass and adiposity are increased black compared to white Americans; the relationship of these increased black compared to white Americans; the relationship of these compartments to skeletal mass and body cell mass are higher in black women, the pattern of involutional loss is similar in blacks and whites. WE further hypothesize that the determinants of bone loss are similar among racial groups and that there is an accelerated loss of body cell mass and skeletal mass following menopause. In this protocol, a cross sectional study of body cell mass, fat, and skeletal mass in 300 normal black women aged 20-80, shall include total body calcium total body potassium, fat, and body fat, and bone mineral density of the radius, proximal femur and lumbar spine. In addition, annual measurement will be performed on 60 women in the 30-40-year and 5-60-year age cohorts. The specific aims are to 1) develop a comprehensive description of aging loss from the total skeleton, the radius, spine and femur; 2) determine the relative influence of peak bone mass and subsequent bone loss on the development of low bone mass; 3) examine the relationship of the loss of body cell mass, skeletal mass, and fat; 4) characterize the determinants of bone loss in various stages of the life cycle. The information derived from this study will provide comprehensive normative data that may be used for evaluation of bone mineral measurement in black women. The similarity or difference from previous studies in white women will suggest the strategies for prevention of bone loss that should be tested.

这项研究的长期目标是制定战略， 用于预防黑人妇女的骨质疏松症。 大多数研究 排除了少数种族以限制无关的变化。 然而，65岁以上的黑人妇女人数 增长迅速。 寿命增加5-6年， 预计会导致发病率翻倍。 体细胞质量退化损失的综合模型， 为白色女性开发的骨量， 预防骨质疏松症，必须制定骨质流失， 少数民族妇女。 身体细胞质量和肥胖增加黑色 与美国白色人相比;这些之间的关系增加 黑人与白色美国人相比; 骨骼质量和体细胞质量的隔间更高， 黑人女性，更年期损失的模式是类似的， 黑人和白人 我们进一步假设， 骨丢失的比例在种族群体之间是相似的， 体细胞质量和骨骼质量的加速损失， 绝经 在这个方案中，一个横断面研究的体细胞质量，脂肪， 300名20-80岁的正常黑人妇女的骨骼质量， 包括全身钙、全身钾、脂肪和身体 脂肪和桡骨、股骨近端和 腰椎 此外，还将进行年度测量 在30-40岁和5-60岁年龄组的60名女性中进行。 的 具体目标是：（1）全面描述 整个骨骼、桡骨、脊柱和股骨的老化损失; 2)确定峰值骨量的相对影响， 随后的骨丢失对低骨量的发展; 3） 研究体细胞质量、骨骼 质量和脂肪; 4）表征骨丢失的决定因素， 生命周期的各个阶段。 从这项研究中获得的信息将提供 可用于评估的全面规范性数据 黑人妇女的骨矿物质测量。 的相似性或 与以前在白色女性中进行的研究的差异表明， 预防骨质流失的策略应该进行测试。