BLACK RACE, BODY COMPOSITION, AND OSTEOPOROSIS

黑人种族、身体成分和骨质疏松症

• 批准号: 3840250
• 负责人: JOHN F ALOIA
• 金额: --
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3840250
• 关键词: African American; activation analysis; aging; body composition; body water; bone density; calcification; calcium; carbon; densitometry; fat body; female; human middle age (35-64); human old age (65+); human subject; isotope dilution method; longitudinal human study; nitrogen; osteoporosis; physiologic bone resorption; potassium; racial /ethnic difference; young adult human (21-34)

The long-term objective of this study is to develop strategies for the prevention of osteoporosis in black women. Most studies have excluded racial minorities to limit extraneous variation. However, the number of black women over 65 years of age is increasing rapidly. An increase in longevity of 5-6 years is expected to cause a doubling of incidence rates. A comprehensive model for involutional loss of body cell mass and bone mass developed for white women, and strategies for prevention of osteoporosis, must be developed for bone loss in minority women. Body cell mass and adiposity are increased black compared to white Americans; the relationship of these increased black compared to white Americans; the relationship of these compartments to skeletal mass and body cell mass are higher in black women, the pattern of involutional loss is similar in blacks and whites. WE further hypothesize that the determinants of bone loss are similar among racial groups and that there is an accelerated loss of body cell mass and skeletal mass following menopause. In this protocol, a cross sectional study of body cell mass, fat, and skeletal mass in 300 normal black women aged 20-80, shall include total body calcium total body potassium, fat, and body fat, and bone mineral density of the radius, proximal femur and lumbar spine. In addition, annual measurement will be performed on 60 women in the 30-40-year and 5-60-year age cohorts. The specific aims are to 1) develop a comprehensive description of aging loss from the total skeleton, the radius, spine and femur; 2) determine the relative influence of peak bone mass and subsequent bone loss on the development of low bone mass; 3) examine the relationship of the loss of body cell mass, skeletal mass, and fat; 4) characterize the determinants of bone loss in various stages of the life cycle. The information derived from this study will provide comprehensive normative data that may be used for evaluation of bone mineral measurement in black women. The similarity or difference from previous studies in white women will suggest the strategies for prevention of bone loss that should be tested.

本研究的长期目标是制定策略 用于预防黑人女性骨质疏松症。 大多数研究 排除了少数族裔以限制无关的变异。 然而，65岁以上的黑人女性数量为 迅速增加。 寿命延长5-6年 预计将导致发病率翻倍。 体细胞质量和退化损失的综合模型 为白人女性开发的骨量以及策略 预防骨质疏松症，必须针对骨质流失制定 少数民族妇女。 体细胞量和脂肪增多黑色 与美国白人相比；这些的关系增加了 黑人与美国白人相比；这些的关系 骨骼质量和体细胞质量的隔室较高 黑人女性的内卷性丧失模式与 黑人和白人。 我们进一步假设决定因素 不同种族群体的骨质流失情况相似，并且存在 体细胞质量和骨骼质量加速损失 绝经。 在该方案中，对体细胞质量、脂肪、 300 名 20-80 岁正常黑人女性的骨骼质量，应 包括全身钙、全身钾、脂肪和身体 桡骨、股骨近端和骨的脂肪和骨矿物质密度 腰椎。 此外，每年都会进行测量 对 60 名 30-40 岁和 5-60 岁年龄组的女性进行了调查。 这 具体目标是 1) 制定一个全面的描述 整个骨骼、桡骨、脊柱和股骨的老化损失； 2) 确定峰值骨量的相对影响和 随后骨质流失导致低骨量的发展； 3） 检查体细胞质量、骨骼的损失之间的关系 质量和脂肪； 4）描述骨质流失的决定因素 生命周期的各个阶段。 从这项研究中获得的信息将提供 可用于评估的综合规范数据 黑人女性的骨矿物质测量。 相似度或 与之前针对白人女性的研究的差异表明 应该测试的预防骨质流失的策略。