BLACK RACE, BODY COMPOSITION, AND OSTEOPOROSIS

黑人种族、身体成分和骨质疏松症

• 批准号: 3855270
• 负责人: JOHN F ALOIA
• 金额: --
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3855270
• 关键词: African American; activation analysis; aging; body composition; body water; bone density; calcium; carbon; densitometry; fat body; female; human middle age (35-64); human old age (65+); human subject; isotope dilution method; longitudinal human study; nitrogen; osteoporosis; physiologic bone resorption; potassium; young adult human (21-34)

The long-term objective of this study is to develop strategies for the prevention of osteoporosis in black women. Most studies have excluded racial minorities to limit extraneous variation. However, the number of black women over 65 years of age is increasing rapidly. An increase in longevity of 5-6 years is expected to cause a doubling of incidence rates. A comprehensive model for involutional loss of body cell mass and bone mass developed for white women, and strategies for prevention of osteoporosis, must be developed for bone loss in minority women. Body cell mass and adiposity are increased black compared to white Americans; the relationship of these increased black compared to white Americans; the relationship of these compartments to skeletal mass and body cell mass are higher in black women, the pattern of involutional loss is similar in blacks and whites. WE further hypothesize that the determinants of bone loss are similar among racial groups and that there is an accelerated loss of body cell mass and skeletal mass following menopause. In this protocol, a cross sectional study of body cell mass, fat, and skeletal mass in 300 normal black women aged 20-80, shall include total body calcium total body potassium, fat, and body fat, and bone mineral density of the radius, proximal femur and lumbar spine. In addition, annual measurement will be performed on 60 women in the 30-40-year and 5-60-year age cohorts. The specific aims are to 1) develop a comprehensive description of aging loss from the total skeleton, the radius, spine and femur; 2) determine the relative influence of peak bone mass and subsequent bone loss on the development of low bone mass; 3) examine the relationship of the loss of body cell mass, skeletal mass, and fat; 4) characterize the determinants of bone loss in various stages of the life cycle. The information derived from this study will provide comprehensive normative data that may be used for evaluation of bone mineral measurement in black women. The similarity or difference from previous studies in white women will suggest the strategies for prevention of bone loss that should be tested.

这项研究的长期目标是制定战略 用于预防黑人女性的骨质疏松。大多数研究 将少数族裔排除在外，以限制外来变异。 然而，65岁以上的黑人妇女人数为 增长迅速。延长5-6年的寿命是 预计会导致发病率翻倍。 体细胞质量退化损失的综合模型 为白人女性开发的骨量，以及 预防骨质疏松症，必须针对骨丢失而开发 少数族裔女性。体细胞质量和肥胖症增加为黑色 与美国白人相比，这些人的关系增强了 黑人与白人的对比；他们之间的关系 间隔与骨骼质量和体细胞质量的比值在 黑人女性，进化损失的模式类似于 黑人和白人。我们进一步假设，决定因素 在种族群体中骨丢失的比例相似，而且有一种 随之而来的身体细胞质量和骨骼质量的加速丧失 更年期。 在这个方案中，对人体细胞质量、脂肪、 和300名20-80岁正常黑人女性的骨量 包括全身钙、全身钾、脂肪和全身 脂肪，以及桡骨、股骨近端和 腰椎。此外，还将进行年度测量 对60名30-40岁和5-60岁年龄组的女性进行了调查。这个 具体目标是1)制定一个全面的描述 全骨骼、桡骨、脊柱和股骨的增龄性丢失； 2)确定峰值骨量的相对影响和 随之而来的骨丢失对低骨量的影响；3) 检查体细胞质量损失与骨骼的关系 体重和脂肪；4)表征骨丢失的决定因素 生命周期的不同阶段。 从这项研究中得出的信息将提供 可用于评估的全面规范数据 黑人女性的骨矿物质测量。相似性或 与以前对白人女性的研究不同，这将表明 预防骨质流失的策略应该进行测试。