NASAL AIRFLOW PATTERNS

鼻腔气流模式

• 批准号: 3838935
• 负责人: DAVID G HORNUNG
• 金额: --
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838935
• 关键词: anosmia; diagnosis design /evaluation; iodine; morphology; nose neoplasm; olfactions; olfactory disorder; olfactory stimulus; physical model; radiography; radionuclides; respiratory airflow disorder; respiratory airflow measurement; sensory disorder diagnosis; statistics /biometry; xenon

Anatomically determined nasal airflow patterns are involved in a number of physiological mechanisms, not the least of which is olfaction. Obviously if the nasal anatomy is such that odorant molecules cannot reach the olfactory region, odorant perception is unlikely. Further, the extent to which the airflow towards the olfactory region is reduced may be reflected in the extent to which olfaction is compromised. Therefore, one of the long range goals of this study is to describe the relationship between nasal anatomy and nasal airflow patterns. This relationship will first be studied in using a radiographic technique that quantifies the airflow patterns through an anatomically correct model of the human nasal passageways. After the normal airflow patterns have been determined, the model will be changed to simulate conditions like nasal spurs, polyps, tumors, and traumatic deformities. The airflow patterns will again be determined, and the extent to which the airflow patterns have changed will be observed. This study will attempt to determine the degree to which the hyposmia that often accompanies the above conditions may be explained by changes in the nasal airflow patterns. Another long term goal of this project is to modify the techniques used in the model in order to visualize the airflow patterns in humans.

解剖学上确定的鼻部气流模式参与了 许多生理机制，其中最重要的是 嗅觉。显然，如果鼻部解剖结构是这样的话 分子不能到达嗅觉区域，气味感知 不太可能。此外，流向的气流的程度 嗅觉区域的减少可能在程度上反映到 哪种嗅觉会受到影响。因此，长距离之一 这项研究的目的是描述鼻腔和鼻腔之间的关系 解剖和鼻部气流模式。这一关系首先将是 研究中使用了一种射线照相技术来量化 通过解剖学上正确的模型的气流模式 人类的鼻腔通道。在正常的气流模式 已确定，模型将更改为模拟 鼻刺、息肉、肿瘤和创伤性疾病 畸形。气流模式将再次确定，并且 气流模式改变的程度将是 观察到的。这项研究将试图确定 通常伴随上述情况的性欲减退 其原因可能是鼻腔气流模式的改变。 这个项目的另一个长期目标是修改技术 在模型中使用，以便可视化中的气流模式 人类。