NASAL AIRFLOW PATTERNS

鼻腔气流模式

• 批准号: 3896629
• 负责人: DAVID G HORNUNG
• 金额: --
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3896629
• 关键词: anosmia; diagnosis design /evaluation; morphology; nose neoplasm; olfactions; olfactory disorder; olfactory stimulus; physical model; radiography; respiratory airflow disorder; respiratory airflow measurement; sensory disorder diagnosis; statistics /biometry; xenon

Anatomically determined nasal airflow patterns are involved in a number of physiological mechanisms, not the least of which is olfaction. Obviously if the nasal anatomy is such that odorant molecules cannot reach the olfactory region, odorant perception is unlikely. Further, the extent to which the airflow towards the olfactory region is reduced may be reflected in the extent to which olfaction is compromised. Therefore, one of the long range goals of this study is to describe the relationship between nasal anatomy and nasal airflow patterns. This relationship will first be studied in using a radiographic technique that quantifies the airflow patterns through an anatomically correct model of the human nasal passageways. After the normal airflow patterns have been determined, the model will be changed to simulate conditions like nasal spurs, polyps, tumors, and traumatic deformities. The airflow patterns will again be determined, and the extent to which the airflow patterns have changed will be observed. This study will attempt to determine the degree to which the hyposmia that often accompanies the above conditions may be explained by changes in the nasal airflow patterns. Another long term goal of this project is to modify the techniques used in the model in order to visualize the airflow patterns in humans.

解剖学上确定的鼻气流模式参与了一个 许多生理机制，其中最重要的是 嗅觉 很明显，如果鼻腔的解剖结构使得气味 分子不能到达嗅觉区域，气味感知 不太可能 此外，气流朝向 嗅觉区域的减少可能反映在 哪种嗅觉受损了 因此，一个长期的 本研究的目的是描述鼻粘膜与 解剖学和鼻腔气流模式。 这种关系将首先是 研究中使用了放射摄影技术， 气流模式通过解剖学上正确的模型， 人类鼻腔通道 在正常的气流模式 确定后，将模型改为模拟 如鼻骨刺，息肉，肿瘤和创伤性疾病 畸形 将再次确定气流模式， 气流模式改变的程度将是 观察 这项研究将试图确定的程度， 嗅觉减退通常伴随着上述情况， 可以通过鼻腔气流模式的变化来解释。 该项目的另一个长期目标是修改技术 在模型中使用，以可视化气流模式， 人类