BRAIN PEPTIDES IN PITUITARY FUNCTIONS AND DIABETES

该提案是一个项目项目的延续，该项目在整个课程中 在过去的16年里，他处理了基本的和 将神经内分泌学应用于糖尿病领域， 脑下垂体和脑功能以及细胞增殖生物学。这个 长期目标是了解关键蛋白质在 糖尿病及其并发症的发生和发展。它是 建议(1)确定血管生成因子是如何调节和识别的 促进和/或限制其生物利用度的机制； 确定这些调节元件在疾病中的功能障碍是如何 糖尿病可能导致微血管并发症；(3)表征 新型生长抑制分子及其在细胞疾病研究中的应用 (4)成纤维细胞生长的分子生物学研究 因子；(5)其受体；(6)其表达的调节。 这些具体的目标将得到最先进的设备的支持 免疫技术的核心，核苷酸合成，肽合成和 测序，一方面作为主干联合全面的 糖尿病、脑下垂体、生长因子生物学等研究项目 另一种是作为开发和引进小说和/或 向研究项目改进技术和技术，以确保 该计划仍然处于科学的前沿。

This proposal is a continuation of a program project that, over the course of the last sixteen years, has dealt with problems in fundamental and applied neuroendocrinology as they apply to the fields of diabetes, pituitary and brain function and the biology of cell proliferation. The long-term objectives are to understand the role played by key proteins in the onset and progression of diabetes and its complications. It is proposed (1) to establish how angiogenic factors are regulated and identify the mechanisms which promote and/or limit their bioavailability; (2) to determine how dysfunction of these regulatory elements in disorders such as diabetes might mediate microvascular complications; (3) to characterize novel growth inhibitors and use these molecules to study diseases of cell proliferation; (4) to study the molecular biology of fibroblast growth factor; (5) its receptor; and (6) the regulation of their expression. These specific aims are to be supported by the presence of state-of-the-art cores of immunotechniques, nucleotide synthesis, peptide synthesis and sequencing, which serve on one hand as the backbone uniting a comprehensive research program in diabetes, pituitary, and growth factor biology and on the other as the necessary resource to develop and import novel and/or improved techniques and technology to the research projects to ensure that the program remains at the forefront of science.