Deciphering the immune complexity that orchestrates T cell activation

解读协调 T 细胞激活的免疫复杂性

• 批准号: DP240102062
• 负责人: Dr Daniel Utzschneider
• 金额: $ 36.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102062
• 关键词: Deciphering; immune; complexity; orchestrates; cell

The adaptive immune system consists of a complex cellular network that can efficiently distinguish exogenous required inputs, such as nutrients, from those that are potentially harmful like pathogens. Such ‘friend-foe’ discrimination has its molecular basis in a multitude of receptors with specificity to certain ligands. Critically, however, it is unclear how such discrimination is mechanistically regulated at the functional level. We have developed new and sophisticated experimental models that will allow us to systematically dissect and unfold the complexity of the adaptive immune system and address this critical knowledge gap. Expected outcomes will critically advance our general understanding of a fundamental biological principle.

适应性免疫系统由一个复杂的细胞网络组成，该网络可以有效地区分外源性所需的输入，如营养物质，以及那些潜在有害的输入，如病原体。这种“敌友”的区别有其分子基础，因为有许多受体对某些配体具有特异性。然而，关键的是，目前还不清楚这种歧视是如何在职能层面上得到机械监管的。我们开发了新的和复杂的实验模型，使我们能够系统地剖析和揭示适应性免疫系统的复杂性，并解决这一关键的知识鸿沟。预期的结果将极大地促进我们对一项基本生物学原理的总体理解。