MYOCARDIAL AND VASCULAR FACTORS IN HEART FAILURE

心力衰竭是一种严重的临床问题，在这种情况下 机制、自然病史和治疗方案在很大程度上仍然 未被开发的。现在很明显，这种综合征代表了一种相互作用 伴有外周血管改变的心肌功能紊乱 功能。心脏和周围在影响中的相对作用 这一疾病过程的进展过程仍不清楚。这 计划项目旨在探索潜在的重要心肌 因素和神经体液对周围血管系统的影响 在实验性心力衰竭的进展中起关键作用 模特和男人。有待研究的心肌因素包括：(1)遗传 火鸡心肌病；(2)火鸡心肌坏死 (3)火鸡的心肌毒素；(4)火鸡的心肌缺血 犬；(5)大鼠心肌梗死：(6)大鼠压力超负荷； (7)人的缺血型和非缺血型心肌功能障碍。 神经体液和外周血管研究将包括：(1) 突触前和突触后α-肾上腺素受体功能； β-肾上腺素受体功能及其下调；(3)肾素-血管紧张素 刺激和阻断；(4)加压素诱导的血管构筑；(5) 血管阻抗测量；(6)局部血流测量；(7) 心钠素测定；和(8)交感神经测定 神经交通。七个项目和四个核心构成了 计划严重依赖于某些方法，包括核 磁共振光谱学，血浆和组织的测量 儿茶酚胺，肾上腺素受体敏感性和密度的评估， 微球测量血流分布与运动负荷的关系 到心肌和外周血管系统。将获得的力量 从方案项目理念上来说，就是思想交流、实验 方法、血液样本和组织，以及生物识别和行政支持 共同努力将促进这一点。

Heart failure is a clinical problem of great magnitude in which the complex mechanisms, natural history and therapeutic options remain largely unexplored. It is now apparent that the syndrome represents an interaction of disturbed myocardial function with altered peripheral vascular function. The relative role of the heart and the periphery in influencing the progressive course of this disease process is still unclear. This Program Project is aimed at exploring potentially important myocardial factors and neurohumoral influences on the peripheral vasculature that may play a critical role in the progression of heart failure in experimental models and in man. Myocardial factors to be studied include: (1) genetic disease of the myocardium in the turkey; (2) myocardial necrosis in the dog; (3) myocardial toxins in the turkey; (4) myocardial ischemia in the dog; (5) myocardial infarcts in the rat; (6) pressure overload in the rat; and (7) ischemic and non-ischemic myocardial dysfunction in man. Neurohumoral and peripheral vascular studies will include: (1) pre-synaptic and post-synaptic Alpha-adrenoreceptor function; (2) beta-adrenoreceptor function and down-regulation; (3) renin-angiotensin stimulation and blockade; (4) vasopressin-induced vasoconstruction; (5) vascular impedance measurements; (6) regional blood flow measurements; (7) atrial natriuretic peptide measurements; and (8) measurement of sympathetic nerve traffic. The seven projects and four cores that constitute the Program are heavily dependent on certain methodology including nuclear magnetic resonance spectroscopy, measurement of plasma and tissue catecholamines, assessment of adrenoreceptor sensitivity and density, microsphere measurement of blood flow distribution and exercise as a stress to the myocardium and peripheral vasculature. The strength to be gained from the Program Project concept is the sharing of ideas, experimental methods, blood samples and tissue, and biometric and administrative support that a joint effort will facilitate.