MYOCARDIAL AND VASCULAR FACTORS IN HEART FAILURE

心力衰竭是一种综合征，在这种综合征中，心脏功能异常， 心肌生物能量学紊乱，神经和神经功能异常 体液循环控制与外周血管功能障碍 音调都有助于临床症状和进展。 失调症的症状。该计划项目探索了每一种异常 在各种实验模型以及心力衰竭患者中 帮助确定导致生理异常的机制 这一过程的特点。先进技术是许多 实验方案。利用超声晶体进行定量 在狗的心脏功能是关键的两个项目，使用 核磁共振波谱评估心肌能量学是 其中三个项目，测量激活的循环荷尔蒙 心力衰竭在三个项目中被利用，微球血流在 在其中两个项目中，心肌是一个关键的血液动力学变量， 去甲肾上腺素动力学、前臂血流量和前臂的测量 动脉顺应性是临床方案的关键特征。这些 研究偏重于药物干预以探索 通过直接刺激或干扰已知药理作用的机制 感受器。调查人员之间的互动包括分享 技术，共享实验模型，以及快速整合 从一个项目发展到其他项目的实验设计。这个 这些研究的长期目标是深入了解 所有这些病理生理事件的性质似乎 对心力衰竭综合征的贡献，希望能有一个 对机理的理解将有助于提高诊断敏锐度 以及治疗上的成功。

Heart failure is a syndrome in which abnormalities in cardiac function, disturbances in myocardial bioenergetics, abnormalities in neural and humoral circulatory control and disturbances in the peripheral vascular tone all contribute to the clinical symptomatology and to the progression of the disorder. This program project explores each of the abnormalities in various experimental models as well as in patients with heart failure to help define mechanisms that contribute to the physiologic abnormality characteristic of the process. Advanced technologies are key to many of the experimental protocols. The use of ultrasonic crystals to quantitate ventricular function in the dog is critical to two of the projects, the use of NMR spectroscopy to assess myocardial energetics is a key component of three of the projects, measurements of circulating hormones activated in heart failure are utilized in three projects, microsphere blood flow in the myocardium is a key hemodynamic variable in two of the projects, and measurements of norepinephrine kinetics, forearm blood flow and forearm arterial compliance are key features of the clinical proposal. These studies lean heavy on pharmacological intervention in order to explore mechanisms by directly stimulating or interfering with known pharmacologic receptors. Interaction among the investigators includes the sharing of technology, sharing of experimental models, and the rapid incorporation of advances from one project into experimental design of other projects. The long-term goal of these studies is to gain insight into the interactive nature of all of these pathophysiologic events that appear to be contributory to the syndrome of heart failure with the hope that an understanding of mechanism will lead to improvements in diagnostic acumen and therapeutic success.