A CLINICAL RESEARCH PROGRAM FOR THE PARTIAL EPILEPSIES

部分性癫痫的临床研究计划

• 批准号: 3099228
• 负责人: JEROME NONE ENGEL
• 金额: $ 103.29万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099228
• 关键词: electroencephalography; human subject; partial seizure; psychobiology; temporal lobe /cortex disorder

The Clinical Neurophysiology Program (CNP) at UCLA makes use of the unique opportunities provided by an epilepsy surgery facility to carry out research on the human brain. In the past, emphasis was placed on clinical research directed toward improving the diagnosis and surgical treatment of epilepsy, although basic research has always been an important part of the program. More recently, resective surgery has become sufficiently accepted as a safe and effective mode of treatment for partial epilepsy to allow clinical activities of the CNP to be supported by hospital funds or supplemented by grants awarded to develop specific diagnostic techniques. In this research proposal we are requesting support only for basic research projects that take advantage of knowledge gained from animal studies and the clinical setting to investigate fundamental mechanisms of normal and abnormal human brain function. Information obtained from patients in our epilepsy surgery facility will be utilized by a multidisciplinary team of basic and clinical neuroscientists to define anatomical and physiological substrates of normal and epileptiform cerebral processes, and to determine how epilepsy related pathological processes might interfere with normal neuronal integration to disrupt behavior during, and between seizures. Specifically, we propose to examine alterations in cellular morphology in epileptogenic tissue and relate these findings to neurotransmitter function, to neuronal activity at the unit level, and to quantitative analysis of spontaneous and stimulation induced field potentials. We also propose to examine anatomical and physiological substrates of sensory processing, memory, and control of cardiorespiratory function. The long term objectives of the CNP are: a. to reveal mechanisms of epileptogenesis in order to suggest new medical, as well as surgical approaches to antiepileptic therapy; b. to better understand the neuronal basis of normal human behavior and mechanisms of pathological disruption that result in abnormal behavior, in order to prevent or more effectively treat behavioral disturbances associated with epilepsy and other neurological disorders; and c. to establish the most effective and efficient presurgical evaluation protocol for epileptic patients who are candidates for resective surgery, in order to allow the greatest number of patients to benefit from this procedure.

加州大学洛杉矶分校的临床神经生理学项目（CNP）利用了独特的 癫痫手术设施提供的机会， 对人类大脑的研究 在过去，重点放在临床 研究旨在改善以下疾病的诊断和手术治疗 癫痫，虽然基础研究一直是一个重要组成部分， 程序. 最近，切除手术已被充分接受 作为部分性癫痫的安全有效的治疗模式， 由医院基金资助的CNP临床活动，或 此外，还为开发具体诊断技术提供赠款。 在这项研究提案中，我们只要求对基础研究提供支持 利用动物研究获得的知识的项目， 临床设置，以研究正常和 异常的人脑功能 从我们的患者中获得的信息 癫痫手术设施将由一个多学科小组使用， 基础和临床神经科学家来定义解剖和生理 正常和癫痫样脑过程的基质，并确定 癫痫相关的病理过程如何干扰正常的 神经元整合以破坏癫痫发作期间和癫痫发作之间的行为。 具体来说，我们建议检查细胞形态的改变， 致癫痫组织并将这些发现与神经递质联系起来 功能，在单位水平上的神经元活动，并定量 分析自发和刺激诱导的场电位。 我们也 建议检查感觉的解剖和生理基础， 处理、记忆和控制心肺功能。 长 “国家计划”的长期目标是：a.揭示癫痫发生的机制 为了提出新的医疗和手术方法， 抗癫痫治疗; B.为了更好地理解正常的神经基础， 人类行为和病理破坏机制，导致 异常行为，以防止或更有效地治疗行为 与癫痫和其他神经系统疾病相关的障碍;以及 C.建立最有效的术前评估 适合切除手术的癫痫患者的方案， 为了让更多的患者从中受益， procedure.