HEAD INJURY CLINICAL AND LABORATORY RESEARCH CENTER

头部损伤临床和实验室研究中心

• 批准号: 3099399
• 负责人: HAROLD F YOUNG
• 金额: $ 112.23万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099399
• 关键词: brain injury; head /neck injury

The main objective of this Head Injury Clinical and Laboratory Research Center is to establish a system whereby rational and improved therapies for patients with head injury can be defined, developed and tested scientifically. To accomplish this objective, the proposed program will (1) define the physiological, morphological, metabolic and psychosocial sequelae of head injury in man; (2) collect, assemble, and analyze data from head injured patients to formulate an accurate prognosis; (3) define in a well controlled animal model the anatomical, physiological and biochemical effects of injury on brain parenchyma and blood vessels and on systemic function. The influence of systemic insults to the injured brain will be studied both in man and in animal models. Evaluations will be made in humans of therapy for brain acidosis, elevated intracranial pressure, ischemic and hyperemic cerebral blood flows, neurophysiological status, and post traumatic mental depression. The role of iatrogenic hypocapnic alkalosis in the management of patients will be clarified. The unifying hypothesis to be tested in that the brain parenchyma and its intrinsic vasculature can sustain reversible injury. These tissue elements can be rendered dysfunctional; yet, such dysfunction does not implicate irreversible disruption. The dysfunctional state may be temporary and if the internal milieu is appropriate for healing, the cells can recover. Dysfunction may be represented by reduced, excessive or aberrant metabolism. An animal intensive care unit and a controlled brain injury model provide the experimental environment. Acute and chronic animal studies will be conducted on morphologic neural and vascular changes, brain glucose utilization, cerebral microcirculation, the brain arachidonic acid cascade, regional cerebral blood flow and surface brain energy metabolism following controlled brain injury. Therapy will be tested by studying cerebral acidosis and treatment with THAM. We seek to understand the fundamental basis of neuronal loss after injury, and, by intervention, to reverse the process.

本研究的主要目的是进行颅脑损伤的临床和实验室研究， 中心的目标是建立一个系统， 可以定义、开发和测试头部受伤的患者， 科学地 为了实现这一目标，拟议方案将 (1)定义生理、形态、代谢和社会心理 人类头部损伤后遗症;（2）收集、整理和分析数据 从头部受伤的病人，以制定准确的预后;（3）定义 在良好控制的动物模型中， 损伤对脑实质和血管的生化影响， 系统功能 全身性损伤对脑损伤的影响 将在人类和动物模型中进行研究。 将进行评估 用于治疗脑酸中毒，颅内压升高， 缺血性和充血性脑血流量、神经生理状态，以及 创伤后精神抑郁 医源性低碳酸血症的作用 将澄清患者管理中的问题。 要检验的统一假设是，脑实质及其 内在脉管系统可维持可逆损伤。 这些组织成分 可能会出现功能障碍;然而，这种功能障碍并不意味着 不可逆转的破坏。 功能失调的状态可能是暂时的，如果 内部环境适合愈合，细胞可以恢复。 功能障碍可表现为减少、过度或异常 新陈代谢. 一个动物重症监护室和一个可控的脑损伤 模型提供了实验环境。 急性和慢性动物 将对形态学神经和血管变化、脑 葡萄糖利用，脑微循环，脑花生四烯酸 级联反应、局部脑血流量和表面脑能量代谢 在控制性脑损伤之后 治疗将通过研究 脑酸中毒和THAM治疗。 我们试图了解 损伤后神经元损失的基本基础，并通过干预， 逆转这个过程。