Placental nutrient transport shows how complex traits evolve

胎盘营养转运显示复杂性状如何进化

• 批准号: DP180103370
• 负责人: A/Prof Camilla Whittington
• 金额: $ 40.09万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103370
• 关键词: Placental; nutrient; transport; shows; how

This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.

该项目旨在以脊椎动物胎盘中的氨基酸运输为模型，展示基因是如何被招募和修饰以产生一个主要器官的。利用新技术、选择性反应监测、转录和分子方法的创新组合，再加上精心挑选的澳大利亚物种对，该项目将研究复杂特征(胎盘氨基酸运输)的进化。该项目将为我们在孕期营养转运方面的知识提供根本性的进步，这是产生健康婴儿所必需的。