RECOVERY & REGENERATION AFTER SPINAL NEURON INJURY

申请续签五年支持的计划为 脊椎动物脊髓神经元损伤的相关研究 电源线。该方案项目的总体目标仍然是 深入了解基本机制的本质 与轴突再生和/或功能恢复相关 在脊髓神经元损伤后。这些项目解决了一些问题 从冷血脊椎动物的功能恢复到 临床症状的哺乳动物模型。这些项目是 多学科结合生理学的方法。 形态和组织化学/分子技术。大多数 项目源自前几年取得的成果 支持。 其中三个项目(2、3和6)是针对自然或 运动功能改变的基础，骨骼或自主神经。之后 脊髓神经元损伤。两个项目(1和2)涉及 中枢神经系统损伤后感觉功能改变的机制 或外周传入通路。一个项目(5)检查 周围神经损伤后引起疼痛状态的可能性 可能是由于交感传出神经之间的相互作用改变所致 和伤害性传入。 虽然六个项目中的每一个都将由一个 独立的调查团队，这两个团队共享一个共同的 对脊髓神经元损伤后果的兴趣，使用了许多 使用相同的技术，并依赖于核心设施来完成 他们的研究目标。

Renewal of support for five years is requested for a program of research related to injury of neurons of the vertebrate spinal cord. The general goal of this program project continues to be to gain insight into the nature of the fundamental mechanisms associated with regeneration of neurites and/or functional recovery after injury to spinal cord neurons. The projects address issues ranging from functional recovery in cold blooded vertebrates to mammalian models of clinical syndromes. The projects are multidisciplinary in approach, combining physiological. morphological and histochemical/molecular techniques. Most of the projects derive from results obtained during previous years of support. Three of the projects (2, 3, and 6) are directed at the nature or bases of changes in motor function, skeletal or autonomic. After injury of spinal neurons. Two projects (1 and 2) concern the mechanisms if altered sensory function following injury to central or peripheral afferent pathways. One project (5) examines the possibility that causalgic states following periphoral nerve injury may result from altered interactions between synpathetic efferents and nociceptive afferents. While each of the six projects will be carried out by an independent team of investigators, the teams share a common interest in the consequences of injury to spinal neurons, use many of the same techniques, and depend on core facilities to accomplish their research goals.