POSSIBLE NEUROPATHIC ORIGIN OF INTERSTITIAL CYSTITIS

这一建议的目的是在病因的综合征主要出现在 女性，间质性膀胱炎（I.C.）。 这项研究的动力来自于 这种综合征的感觉症状突出， 出现I.C.在那些可能遭受创伤性损伤的女性中， 盆腔结构或盆腔疾病。 的可能性 骨盆区域的神经损伤可导致自主神经病变 以某种方式影响感觉纤维，与躯体综合征相当， 卡塔尼亚，有待探索。 自主神经传出神经所产生的效应 对膀胱传入神经的活动进行测试，以及部分去神经 任何影响都要检查。 问题是是否部分 去神经支配导致剩余或 再生的传入神经元供应膀胱， 通过自主活动变得兴奋，并引起体征， I.C.的症状该研究提出了一个系统的调查范围， 膀胱测压生理性兴奋传入纤维的特性 膀胱扩张的正常成年大鼠，以建立一个 对照组基线。 作为这项调查的一部分，计划收集 关于这种膀胱传入单位的子集是否 专门用于检测过度膨胀。 刺激效应 自主传出神经的膀胱和自主化学 介质（去甲肾上腺素、Sp、VIP、神经肽Y、胆碱能、ATP 类似物）对这些传入特征的影响将被检查。 有多片面 腹下、骨盆或交感神经损伤引起的去神经支配 神经（在无菌手术条件下）改变任何自主神经 然后将评估感觉器官特性的调节。 等 关于膀胱感觉器官的信息及其变化 在模拟临床条件的情况下， 是一个新的贡献，并提供了重要的洞察力，一个可能的- I.C.感觉神经元病因学 它有可能开启新的 治疗这种综合征和其他内脏疾病的方法 可能的神经病性疾病。

This proposal is aimed at the etiology of a syndrome largely appearing in women, interstitial cystitis (I.C.). The impetus for the study comes from the prominence of sensory symptoms in this syndrome and a predominant occurrence of I.C. in women who may have suffered traumatic injury of pelvic structures by childbearing or pelvic disease. The possibility that neural damage in the pelvic region can lead to an autonomic neuropathy affecting sensory fibers in some way comparable to the somatic syndrome, causalgia, is to be explored. The effects produced by autonomic efferent activity on bladder afferents are to be tested and how partial denervation modifies any effects is to be examined. The issue is whether partial denervation leads to alterations in characteristics of remaining or regenerated afferent neurons supplying the urinary bladder so, that they become excited by autonomic activity and give rise to the signs and symptoms of I.C. The study proposes a systematic survey of the range of characteristics of afferent fibers excited by cystometric physiological distension of the bladder in normal adult rats in order to establish a control group baseline. As part of this survey, it is planned to gather information on whether a subset of such bladder afferent units are specialized for detection of excessive distention. Effects of stimulation of autonomic efferent nerves to the bladder and of autonomic chemical mediators (norepinephrine, Sp, VIP, neuropeptide Y, cholinergics, ATP analogues) on such afferent characteristics will be examined. How partial denervation produced by injury of the hypogastric, pelvic or sympathetic nerves (under sterile surgical conditions) modifies any autonomic modulation of sense, organ characteristics will then be evaluated. Such information on sense organs of the bladder and modifications in their characteristics under circumstances simulating clinical conditions would be a novel contribution and provide important insight into a possible- sensory neuron etiology of I.C. It has the potential of opening new approaches to treatment of this syndrome and that of other visceral disorders of possible neuropathic origin.